Mir-652 microRNA precursor family

mir-652
mir-652
Identifiers
Symbol	mir-652
Rfam	RF00872
miRBase family	MIPF0000333
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-652 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, with expression levels of miRNAs and respective target mRNAs negatively correlated.

Lineage

miR-652 expression is specific to cells of the myeloid lineage, in this instance to monocytes and granulocytes.^[1]

miR-652 and liver cirrhosis

miR-652 serum levels are significantly altered in alcoholic- or hepatitis-C-induced liver cirrhosis patients. They have been found to be down-regulated in the circulating monocytes of such patients, thus supporting the idea of an miR-652 role in the mediation of fibrogenic and inflammatory processes in the pathogenesis of liver cirrhosis.^[2]

Expression in liver cancer

Circulating levels of miR-652 show gradual elevation with progression of liver cancer, as is also the case with miRNAs let-7a, let-7f, miR-34a, miR-98, miR-331 and miR-338.^[3]

References

^ Allantaz F, Cheng DT, Bergauer T, Ravindran P, Rossier MF, Ebeling M, et al. (2012). "Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression". PLOS ONE. 7 (1): e29979. Bibcode:2012PLoSO...729979A. doi:10.1371/journal.pone.0029979. PMC 3262799. PMID 22276136.
^ Roderburg C, Mollnow T, Bongaerts B, Elfimova N, Vargas Cardenas D, Berger K, et al. (2012). "Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis". PLOS ONE. 7 (3): e32999. Bibcode:2012PLoSO...732999R. doi:10.1371/journal.pone.0032999. PMC 3296762. PMID 22412969.
^ Sukata T, Sumida K, Kushida M, Ogata K, Miyata K, Yabushita S, Uwagawa S (January 2011). "Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages". Toxicology Letters. 200 (1–2): 46–52. doi:10.1016/j.toxlet.2010.10.013. PMID 21035526.

External links

Page for mir-652 microRNA precursor family at Rfam

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[pmid22276136-1] Allantaz F, Cheng DT, Bergauer T, Ravindran P, Rossier MF, Ebeling M, et al. (2012). "Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression". PLOS ONE. 7 (1): e29979. Bibcode:2012PLoSO...729979A. doi:10.1371/journal.pone.0029979. PMC 3262799. PMID 22276136.

[pmid22412969-2] Roderburg C, Mollnow T, Bongaerts B, Elfimova N, Vargas Cardenas D, Berger K, et al. (2012). "Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis". PLOS ONE. 7 (3): e32999. Bibcode:2012PLoSO...732999R. doi:10.1371/journal.pone.0032999. PMC 3296762. PMID 22412969.

[pmid21035526-3] Sukata T, Sumida K, Kushida M, Ogata K, Miyata K, Yabushita S, Uwagawa S (January 2011). "Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages". Toxicology Letters. 200 (1–2): 46–52. doi:10.1016/j.toxlet.2010.10.013. PMID 21035526.

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