MS 618 begins in downtown Moss Point at an intersection with MS 613 (Main Street). It heads east along McInnis Avenue to cross a railroad track to leave downtown and travel through neighborhoods for several blocks as it begins paralleling the Escatawpa River, where it merges onto Elder Street, then Grierson Street. The highway has an intersection with MS 63 and heads northeast through more neighborhoods, passing by a few businesses and crosses a small bayou, before leaving Moss Point. MS 618 curves back to the east and enters the small community of Orange Grove, where it merges onto Old Stage Road for a short distance before making a sharp right turn and coming to an end at an intersection with US Highway 90 (US 90). Old Stage Road continues northeast along the original two-lane alignment of US 90.
The entire length of Mississippi Highway 618 is an unsigned two-lane state highway.[2]
