Mouse brain development timeline

The house mouse (Mus musculus) has a gestation period of 19 to 21 days. Key events in mouse brain development occur both before and after birth, beginning with peak neurogenesis of the cranial motor nuclei 9 days after conception, up to eye opening which occurs after birth and about 30 days after conception.

Stages in brain development

Days post conception Event Reference
9 cranial motor nuclei - peak of neurogenesis Finlay and Darlington (1995)
10 subplate -start of neurogenesis Bayer and Altman (1991)
10 inferior olivary nucleus - peak of neurogenesis Finlay and Darlington (1995)
10.5 retinal ganglion cell generation - start of neurogenesis Robinson and Dreher (1990)
10.5 superficial superior colliculus (SC) laminae- start of neurogenesis Robinson and Dreher (1990)
10.5 dorsal lateral geniculate nucleus (dLGN) - start of neurogenesis Robinson and Dreher (1990)
10.5 Purkinje cells - peak of neurogenesis Finlay and Darlington (1995)
11 cranial sensory nuclei - peak of neurogenesis Finlay and Darlington (1995)
11 subplate - peak of neurogenesis Finlay and Darlington (1995)
11 reticular nuclei - peak of neurogenesis Finlay and Darlington (1995)
11 medial geniculate nucleus - peak of neurogenesis Finlay and Darlington (1995)
11 globus pallidus - peak of neurogenesis Finlay and Darlington (1995)
11.5 ventral LGN - peak of neurogenesis Finlay and Darlington (1995)
12 dLGN - peak of neurogenesis Finlay and Darlington (1995)
12 cochlear nuclei - peak of neurogenesis Finlay and Darlington (1995)
12 mitral cells - peak of neurogenesis Finlay and Darlington (1995)
12 amygdala - peak of neurogenesis Finlay and Darlington (1995)
12 subplate - end of neurogenesis Bayer and Altman (1991)
12.3 axons in optic stalk Dunlop et al. (1997)
12.5 ventral posterior nucleus (VP) and ventrobasal nucleus (VB) of the thalamus - peak of neurogenesis Finlay and Darlington (1995)
12.5 nucleus of lateral olfactory tract - peak of neurogenesis Finlay and Darlington (1995)
12.5 claustrum - peak of neurogenesis Finlay and Darlington (1995)
12.5 neurogenesis cortical layer VI - peak (VC) of neurogenesis Finlay and Darlington (1995)
12.5 dLGN- end of neurogenesis Robinson and Dreher (1990)
12.5 preoptic nucleus - peak of neurogenesis Finlay and Darlington (1995)
13 medial forebrain bundle appears Ashwell et al. (1996)
13 suprachiasmatic nucleus - peak of neurogenesis Finlay and Darlington (1995)
13 optic axons at chiasm of optic tract Dunlop et al. (1997)
13 superior colliculus - peak of neurogenesis Finlay and Darlington (1995)
13 retinal ganglion cells - peak of neurogenesis Finlay and Darlington (1995)
13 septal nuclei - peak of neurogenesis Finlay and Darlington (1995)
13 entorhinal cortex - peak of neurogenesis Finlay and Darlington (1995)
13 subiculum – peak of neurogenesis Finlay and Darlington (1995)
13 neurogenesis cortical layer V - peak (VC) of neurogenesis Finlay and Darlington (1995)
13 neurogenesis cortical lamina VI - end (VC) of neurogenesis Caviness (1982)
13.5 raphe complex - peak of neurogenesis Finlay and Darlington (1995)
13.5 anterior olfactory nucleus - peak of neurogenesis Finlay and Darlington (1995)
13.5 anteroventral (AV), anterodorsal (AD) and anteromedial (AM) thalamic nuclei - peak of neurogenesis Finlay and Darlington (1995)
13.5 pontine nuclei – peak of neurogenesis Finlay and Darlington (1995)
13.5 parasubiculum – peak of neurogenesis Finlay and Darlington (1995)
13.5 stria terminalis appears Ashwell et al. (1996)
13.5 presubiculum – peak of neurogenesis Finlay and Darlington (1995)
14 fasciculus retroflexus appears Finlay and Darlington (1995)
14 caudoputamen – peak of neurogenesis Finlay and Darlington (1995)
14 superficial SC laminae - end of neurogenesis Robinson and Dreher (1990)
14 fornix appears Ashwell et al. (1996)
14 cones - peak of neurogenesis Finlay and Darlington (1995)
14 neurogenesis cortical layer V - end (VC) of neurogenesis Caviness (1982)
14.5 optic axons reach dLGN and SC Robinson and Dreher (1990)
14.5 anterior commissure appears Ashwell et al. (1996)
15 neurogenesis cortical lamina IV - start (VC) of neurogenesis Caviness (1982)
15 CA 1, CA 2 of hippocampus - peak of neurogenesis Finlay and Darlington (1995)
15 retinal amacrine cells - peak of neurogenesis Finlay and Darlington (1995)
15 hippocampal commissure appears Ashwell et al. (1996)
15 neurogenesis cortical layer II /III - peak (VC) of neurogenesis Finlay and Darlington (1995)
15.5 optic axons invade visual centers Dunlop et al. (1997)
16 nucleus accumbens - peak of neurogenesis Finlay and Darlington (1995)
16 tufted cells - peak of neurogenesis Finlay and Darlington (1995)
16 isles of Calleja - peak of neurogenesis Finlay and Darlington (1995)
17 neurogenesis cortical layer IV - peak (VC) of neurogenesis Caviness (1982)
17 corpus callosum appears Ashwell et al. (1996)
17 neurogenesis cortical layer IV - end (VC) of neurogenesis Bayer and Altman (1991)
18.5 retinal ganglion cell generation - end of neurogenesis Robinson and Dreher (1990)
19 initial differentiation of layer V (S1) Finlay and Darlington (1995)
19 rods - peak of neurogenesis Finlay and Darlington (1995)
21 complete separation of layer V (S1) Rice et al. (1985)
22 onset of barrels (S1) Rice et al. (1985)
22 onset of sublayers in layer V (S1) Rice et al. (1985)
22 onset of trilaminar plate (S1) Rice et al. (1985)
24 onset of barrel field septa (S1) Rice et al. (1985)
25.5 ipsi/contra segregation in LGN and SC Robinson and Dreher (1990)
30 eye opening Dunlop et al. (1997)

References

  • Ashwell, K.W.S.; Waite, P.M.E.; Marotte, L. (1996). "Ontogeny of the Projection Tracts and Commissural Fibres in the Forebrain of the Tammar Wallaby (Macropus eugenii): Timing in Comparison with Other Mammals". Brain, Behavior and Evolution. 47 (1). S. Karger AG: 8–22. doi:10.1159/000113225. ISSN 0006-8977. PMID 8834781.
  • Clancy, B., Kersh, B., Hyde, J., Darlington, R.B., Anand, K.J.S., Finlay, B.L., 2007. Web-Based Method For Translating Neurodevelopment From Laboratory Species To Humans. Neuroinformatics. 5, pp. 79–94.
  • Dunlop, S.A.; Tee, L.B.; Lund, R.D.; Beazley, L.D. (1997). "Development of primary visual projections occurs entirely postnatally in the fat-tailed dunnart, a marsupial mouse, Sminthopsis crassicaudata". J. Comp. Neurol. 384 (1): 26–40. doi:10.1002/(sici)1096-9861(19970721)384:1<26::aid-cne2>3.0.co;2-n. PMID 9214538. S2CID 38381685.
  • Finlay, BL; Darlington, RB (1995-06-16). "Linked regularities in the development and evolution of mammalian brains". Science. 268 (5217): 1578–84. Bibcode:1995Sci...268.1578F. doi:10.1126/science.7777856. ISSN 0036-8075. PMID 7777856.
  • Robinson, Stephen R.; Dreher, Bogdan (1990). "The Visual Pathways of Eutherian Mammals and Marsupials Develop According to a Common Timetable". Brain, Behavior and Evolution. 36 (4). S. Karger AG: 177–195. doi:10.1159/000115306. ISSN 1421-9743. PMID 2279233.

See also

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