My Binondo Girl is the story of Jade Dimaguiba, a girl who spent her life seeking the approval and acceptance of her Chinese father Chen Sy (Richard Yap), who attempted to put her up for adoption when she was young because of China's One Child Policy (wherein couples either put their first child up for adoption or pay a government fine to have a second child).
His decision was swiftly made after learning that his Filipina wife Zeny (Ai-Ai delas Alas) is pregnant with a baby boy, which is more favored under the Chinese tradition. In order to protect her child, Zeny returns to the Philippines only to suffer a miscarriage and lose the second child.
Years after, Chen Sy, already a successful business tycoon, finds Zeny to see Yuan, the baby boy. Zeny refuses to tell him his whereabouts but despite this, Chen continues to ignore Jade and disregard her as his daughter. Jade vows to gain her father's acceptance someday and graduates with top honors to prove to her father that despite her gender, she is a worthy daughter.
However, in an unexpected turn of events, Chen loses his other son Chen Sy II (from his second marriage) to an accident and Jade is forced to pose as Yuan in order to get her mother and grandmother Amor (Gina Pareño) out of jail because of Jean (Cherry Pie Picache), the second wife's machinations. Jade is helped through her journey by Onyx (Jolo Revilla), her childhood friend and determined suitor; Trevor (Matteo Guidicelli), the happy go lucky stepson of her father's business partner; and Andy (Xian Lim), who started off as her competition but ended up as one of her staunchest supporters upon learning her dual identity.
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