The plot focuses on Ruth and Eileen Sherwood, sisters from Ohio who relocate to New York City in search of fame and fortune. Witty Ruth aspires to be a published writer, while pretty Eileen dreams of success as an actress. Their financial circumstances force them to rent a dingy basement studio apartment in a Greenwich Village building owned by Mr. Appopoulos, one of many colorful characters who cross their path.
Eileen McKenney, an executive assistant to Walt Disney and the inspiration for the play's title character, and her husband, novelist and screenwriter Nathanael West, were killed in an automobile accident in El Centro, California on December 22, 1940, four days before the Broadway opening, while they were driving to the Los Angeles Airport to board a plane for New York to attend the play's premiere. Her sister Ruth consequently did not attend the premiere and never saw the play.[2]