N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase.^[1][2] This enzyme catalyses the following chemical reaction

(1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine ${\displaystyle \rightleftharpoons }$ adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine

(2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine ${\displaystyle \rightleftharpoons }$ adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine

The enzyme is activated by divalent cations and reduced glutathione.

• CHST15

• N-acetylgalactosamine+4-sulfate+6-O-sulfotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)