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NPLOC4
Identifiers
Aliases	NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
External IDs	OMIM: 606590; MGI: 2679787; GeneCards: NPLOC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PJH
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,648,465 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,328,534 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; apex of heart; ; muscle of thigh; ; stromal cell of endometrium; ; right testis; ; right coronary artery; ; islet of Langerhans; ; left testis; ; left ventricle; ; right adrenal gland;
	Top expressed in
	spermatocyte; ; muscle of thigh; ; cumulus cell; ; interventricular septum; ; ascending aorta; ; aortic valve; ; spermatid; ; supraoptic nucleus; ; seminiferous tubule; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin binding; protein binding; metal ion binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; cytosol; nuclear outer membrane-endoplasmic reticulum membrane network; endoplasmic reticulum; nucleus; UFD1-NPL4 complex; nucleoplasm; VCP-NPL4-UFD1 AAA ATPase complex;
Biological process	error-free translesion synthesis; retrograde protein transport, ER to cytosol; Golgi organization; ubiquitin-dependent ERAD pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of type I interferon production; negative regulation of RIG-I signaling pathway; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55666
	217365
	ENSG00000182446
	ENSMUSG00000039703
	Q8TAT6
	P60670
	NM_017921; NM_001369698
	NM_001195023; NM_199469
	NP_060391; NP_001356627; NP_060391.2
	NP_001181952; NP_955763
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.^[5]^[6]^[7]

Interactions

NPLOC4 has been shown to interact with UFD1L.^[5]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182446 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039703 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
^ Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.
^ "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".
^ Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

McConnell E, Lass A, Wójcik C (2007). "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation". Biochem. Biophys. Res. Commun. 355 (4): 1087–90. Bibcode:2007BBRC..355.1087M. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182446 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039703 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11574150-5] Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.

[pmid10811609-6] Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.

[entrez-7] "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".

[pmid18586029-8] Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

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NPLOC4

Interactions

References

Further reading

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