ARTIKELDIGITAL.COM

Factor 2 (NRF2) or nuclear factor erythroid-derived 2-like 2 (NFE2L2), is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic...

structure, which is where Keap1 interacts with Nrf2. Keap1 functions as a negative regulator of Nrf2, a master regulator of the cellular antioxidant...

biology, the Nrf2 internal ribosome entry site (IRES) is an RNA element present in the 5′ UTR of the mRNA encoding the transcription factor Nrf2. It contains...

the antioxidative transcription factor Nrf2 and inhibition of the pro-inflammatory transcription factor NF-κB. Nrf2 transcriptionally regulates multiple...

that combines direct inhibition of the NLRP3 inflammasome, induction of NRF2, and release of nitric oxide under hypoxic conditions. It has received Fast...

nitrosamine-induced carcinogenesis (likely due to phase-II enzyme induction via Nrf2). The EFSA considers TBHQ to be noncarcinogenic. A 1986 review of scientific...

anti-inflammatory drugs, which dually activate the antioxidative transcription factor Nrf2 and inhibit the pro-inflammatory transcription factor NF-κB. The last CEO...

Pre-clinical studies indicate that the compound acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. A phase 3 clinical trial evaluating...

through the Keap1/Nrf2/ARE. Keap1 acts as the sensor which loses its ability to target Nrf2 for degradation upon exposure to the inducers. Nrf2 is consequently...

main active metabolite monomethyl fumarate. This metabolite activates the NRF2 transcriptional pathway, which reduces inflammation and modulates the activity...

activation of the Nrf2 mediates intermittent hypoxia (IH) cardiomyopathy protection. Transgenic mice with a deletion of any Nrf2 gene (Nrf2-KO) are highly...

genes and metabolism genes. The Nrf2-sMaf heterodimers are critical for oxidative and electrophilic stress response. Nrf2 is known as a master regulator...

of certain genes. Retention of Nrf2 in the cell's cytosol also promotes its degradation by E3 ubiquitin ligase. Nrf2: a) inhibits its target genes from...

A, Arase S, Imaoka S (October 2020). "WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes". Drug Metabolism and Pharmacokinetics....

through the nuclear factor erythroid 2 related factor 2 (Nrf2) pathway. Under normal conditions the Nrf2 is bound to Kelch-like ECH associated protein 1 (Keap1)...

sulfide acts to reduce or disrupt ROS levels in cells via activation of Nrf2, which is known to increase the levels of glutathione. H2S has been shown...

Mice (The db/db mice are perfect animal models of type 2 diabetes.) via Nrf2/HO-1 and NF-κB-Mediated Pathways Trametenolic Acid Mitigated Oxidative Stress...

hydrogen peroxide and electrophilic compounds. Mouse Mafg gene is induced by Nrf2-sMaf heterodimers through an antioxidant response element (ARE) at the promoter...

factor 2 (Nrf2) pathway and monomethyl fumarate has been identified as a nicotinic acid receptor agonist in vitro. In mice that lack Nrf2 expression...

kinas-inhibiting drug, to treat NSV. As of 2024, mitochondrial antioxidants, NRF2 inhibitors, and TBK1 inhibitors were emerging as potential therapeutic options...

provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism". The Journal of Neuroscience. 30 (16): 5525–5532. doi:10...

A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J (September 2016). "Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily...

(2017). "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism". Aging Cell. 16 (3): 564–574. doi:10.1111/acel.12587...

relapse and disability progression in a phase 3 trial. It activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic...

Zimmermann K, Heiss EH, Dirsch VM, et al. (March 2013). "Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo". Molecular...

anti-inflammatory and antioxidant properties by modulating the SIRT1 and NRF2 signaling pathways. This activation reduces the production of reactive oxygen...

weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer". Aging Cell. 15 (5): 872–884. doi:10.1111/acel.12496. ISSN 1474-9718...

Information. 38 (2): 428. 2024. Chang KH, Chen CM (May 2024). "The Role of NRF2 in Trinucleotide Repeat Expansion Disorders". Antioxidants. 13 (6): 649....

1002/bies.20849. PMID 18937349. Nguyen T, Nioi P, Pickett CB (May 2009). "The Nrf2-antioxidant response element signaling pathway and its activation by oxidative...

and prompting RS in cells. Nuclear factor erythroid 2–related factor 2 (Nrf2) is an important transcription factor that regulates a multitude of genes...

investigated than MCTs 5-14. MCTs can be upregulated by PPAR-α, HIF-1α, Nrf2, and AMPK. Lactate has long been considered a byproduct resulting from glucose...

Gureev AP, Popov VN, Starkov AA (June 2020). "Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation"...

with alterations to CDKN2A, SETD2, TFE3, or increased expression of the NRF2–ARE pathway; loss of expression of CDKN2A and CpG island methylation phenotype...

"N-acetyl-l-cysteine ethyl ester (NACET) induces the transcription factor NRF2 and prevents retinal aging and diabetic retinopathy". Redox Biology. 88 103914...

"Activation of GABBR1 by New Ligand Valerate Transcriptionally Regulates ATF4-NRF2-CXCL13 Axis Mediating CD8+ T Cell Anti-Tumor Immunity". Int J Biol Sci. 22...

Stress: Current Perspectives on the Role of NRF2 showed that the factor responsible for antioxidant regulation, NRF2, is inhibited after prolonged wakefulness...

Hannink M (August 2006). "Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling". The EMBO Journal. 25 (15): 3605–17....

Additionally, high plasma levels comparable to those in animal models where Nrf2 was activated were achieved. The various forms of LA are not bioequivalent...

ROS (Reactive Oxygen Species) through enhancement of gene expression of Nrf2, HO-1, and anti-oxidant enzymes, such as CAT, GSH, and SOD. Crocin and its...

heat stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249 114411...

Researchers find that two molecules, rod-derived cone viability factor (RdCVF) and Nrf2, can protect cone photoreceptors in mouse models of retinitis pigmentosa...

formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway". Scientific Reports. 7 (1): 11551. Bibcode:2017NatSR...711551H...

such as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMaf homodimers...

(Nuclear factor erythroid 2-related factor 2) transcription factor. NFE2L2 (or NRF2) is a basic leucine zipper (bZIP) protein that regulates the expression of...

"Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae)". PLOS ONE. 11 (1) e0146274...

(February 2015). "Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells". Free Radical Biology & Medicine. 79: 164–175. doi:10...

known, though some studies have shown that the AOX1 gene is regulated by the Nrf2 pathway. Some known inhibitors of AO are sterol and phenol compounds, like...

individually and in combination protect against oxidative stress via the Nrf2-ARE pathway". Food and Chemical Toxicology. 62: 869–875. doi:10.1016/j.fct...

Shahira; Raafat, Eman M.; Eissa Ahmed, Amany Ali (2021-09-15). "Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons...

ameliorates CCl4 -induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway". Journal of Cellular and Molecular Medicine. 22...

2009). "Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice". Toxicology Letters. 185 (3): 180–186. doi:10.1016/j.toxlet...

Thimmulappa, Rajesh K.; et al. (15 September 2002). "Identification of Nrf2-regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide...

2017). "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism". Aging Cell. 16 (3): 564–574. doi:10.1111/acel.12587...

ability to regenerate lost appendages. P21 has been shown to interact with: Nrf2 BCCIP, CIZ1, CUL4A, CCNE1, CDK, DDB1, DTL, GADD45A, GADD45G, HDAC, PCNA,...

ischemia-related reperfusion injury through ferroptosis inhibition (via Nrf2/GPX4/SLC7A11 pathway) or by mitochondrial membrane potential stabilization...

and mitochondrial DNA transcription and replication. Nrf1, together with Nrf2, mediates the biogenomic coordination between nuclear and mitochondrial genomes...

Gregorio; Al-Dalaien, Said M. (September 2017). "Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines...

intimately associated with the p62-KEAP1-NRF2 pathway, a significant oxidative stress regulator. Usually, KEAP1 binds NRF2 and targets it for degradation, but...

Bulbophyllum moratii Wikidata: Q4995186 APDB: 207283 BOLD: 1088370 CoL: NRF2 EoL: 252988 GBIF (old): 2846071 iNaturalist: 494159 IPNI: 937616-1 IUCN:...

binding sites for Nrf2. Nrf2 is a major regulator of the antioxidant response to ROS within the cell. Klf9 is upregulated by Nrf2; when oxidative stress...

transcriptional activity of nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and stimulates the expression of peroxisome proliferator-activated receptor...

weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer". Aging Cell. 15 (5): 872–884. doi:10.1111/acel.12496. PMC 5013015...

such as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMafs regulate...

"ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway". Autophagy. 16 (5): 917–931. doi:10.1080/15548627...

been described. Other genes involved affected by this mutation are Keap1, Nrf2 and HMOX1. The diagnosis is made either by testing of the fumarate hydratase...

activities. It enhances the activity of GABAA receptors. It also activates Nrf2 in neurons and astroglia, providing protection against amyloid-β-induced...

storage proteins in the endosperm of maize (Zea mays) kernels NFE2L2 or Nrf2 Bzip Maf transcription factors ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1;...

Recent (2021) research indicates that salazinic acid is a potent modulator of Nrf2, NF-κB and STAT3 signaling pathways in colorectal cancer cells. The complete...

Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, et al. (June 2018). "Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis...

febuxostat-chitosan nanoparticles for promoting gouty arthritis with hyperuricemia via Nrf2/NF-κB/NLRP3 and VEGF pathways". Journal of Drug Delivery Science and Technology...

ii) peptides such as adrenomedullin and apolipoprotein; and iii) hemin. NRF2 inducers with downstream HO-1 induction include: genistein, 3-hydroxycoumarin...

nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2). The PI3K/NRF2 pathway signaling triggers several responses, such as the expression...

sequence, associates with Nrf2 and MafK (Nrf2–MafK) via basic leucine zipper domains, and increases DNA-binding activity of the Nrf2–MafK complex to the ARE...

to interact with: MAP1LC3A, PRKCI, RAD23A, RIPK1, TRAF6 TrkA, and TrkB. Nrf2 The SQSTM1 gene, which is actively transcribed as part of normal cellular...

the activation of antioxidant pathways including the transcription factor Nrf2. Stimulator of nerve growth factor (NGF) synthesis in vitro((250.1 ± 36.2)...

human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2". The Journal of Biological Chemistry. 272 (26): 16490–7. doi:10.1074/jbc...

conditions, SETD6 and DJ1 associate with chromatin which inhibits DJ1 to activate Nrf2 transcription activity. In response to oxidative stress, SETD6 mRNA and protein...

lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway". Scientific Reports. 7 46208. Bibcode:2017NatSR...746208F. doi:10...

Researchers at ChristianaCare's Gene Editing Institute report that disabling the NRF2 gene with CRISPR can reverse chemotherapy resistance in lung cancer, restoring...

inflammation-regulating genes. LXA4 stimulates various cell types to promote the entry of Nrf2 into the nucleus and thereby to increase the expression of genes such as...

(April 2014). "(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways". Annals of Clinical and Translational Neurology. 1 (4): 258–271...

support bone regeneration more effectively by delivering a protective gene (Nrf2) and a steroid (dexamethasone). Other flow cytometry-based methods allow...

receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional...

PMID 21148084. Martín-Montalvo A, Villalba JM, Navas P, de Cabo R (February 2011). "NRF2, cancer and calorie restriction". Oncogene. 30 (5): 505–520. doi:10.1038/onc...

Qu J, Shen X (May 2008). "NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK". Biochimica...

1016/S0021-9258(18)54105-3. PMID 8380166. Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated...

activation of Nrf2's induction of antioxidant proteins. The ability of cyclopentenone prostaglandins to promote the transcription of Nrf2-dependent genes...

D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways". Toxicology and Applied Pharmacology. 260 (1): 35–47. doi:10...

"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain". Genes & Development....

reversal of the epithelial-mesenchymal transition and the activation of the Nrf2 antioxidant system without causing systemic toxicity, L-abrine may be effective...

doi:10.1074/jbc.272.51.32163. PMID 9405416. Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated...

Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway". Mol Neurobiol. 56 (1): 39–55. doi:10.1007/s12035-018-1020-1...

Epithelial A549 Cells from Oxidative Injury Induced by Particulate Matter via Nrf2 Signaling Pathway". Molecules. 27 (1): 253. doi:10.3390/molecules27010253...

2025). "Silencing PADI-2 induces antitumor effects by downregulating NF-κB, Nrf2/HO-1 and AKT1 in A549 lung cancer cells". International Immunopharmacology...

cancer, the overexpression of Cullin 3 protein results in a decrease of Nrf2 protein level. This protein is a transcription factor regulating the expression...

Banning A, Deubel S, Kluth D, et al. (2005). "The GI-GPx gene is a target for Nrf2". Mol. Cell. Biol. 25 (12): 4914–23. doi:10.1128/MCB.25.12.4914-4923.2005...

YM, et al. (July 2023). "RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats". Heliyon. 9 (7) e18160. doi:10...

alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice". Acta Biochimica et Biophysica Sinica. 56 (4):...

Bell, D.A., & Slattery, M. (2015). Beyond antioxidant genes in the ancient Nrf2 regulatory network. Free radical biology & medicine, 88 Pt B, 452-465 . doi:10...

undisclosed amount. Orthotrophix American Reagent AKL4 / APPA Oral NFkB and Nrf2 modulator National Institute for Health Research (NIHR)-approved Phase I...

DPP3 activates the KEAP1-NRF2 antioxidant pathway, which helps combat oxidative stress. It does this by competing with NRF2 to bind to KEAP1, releasing...

attenuated Naje haje venom-induced cellular dysfunctions via modulation of Nrf2 and inflammatory signalling pathways in rats". Biochemistry and Biophysics...

in papillary adenocarcinoma, highlighting its important role in the KEAP1–NRF2 pathway, which regulates antioxidant responses, enzyme detoxification, and...

2001). "Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation". The...

2017). "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism". Aging Cell. 16 (3): 564–574. doi:10.1111/acel.12587...

N.; Mele, James; Hayes, John D.; Buffenstein, Rochelle (November 2010). "Nrf2, a guardian of healthspan and gatekeeper of species longevity". Integrative...

upregulation correlates with poor prognosis. FSP1 is a NRF2 targeted gene and contributes to NRF2-dependent ferroptosis resistance. Loss of FSP1 in preclinical...

preclinical studies it activated nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor that is up-regulated under oxidative stress. The...

species. One such HYCO includes a dimethyl fumarate moiety which activates NRF2 to thereby induce HO-1, whilst the CORM moiety also liberates CO. Carbon...

translation of the N-terminally truncated Ure2. Ure2 Internal ribosome entry site Nrf2 internal ribosome entry site (IRES) Komar, AA; Lesnik, T; Cullin, C; Merrick...

Jacqueline Y.; Paek, Jennifer; Curran, Sean P. (2014-10-06). "SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation"...

to downregulate PGC-1α, but upregulate its downstream effectors, NRF1 and NRF2. Akt itself is activated by PIP3, often upregulated by PI3K after G protein...

be antioxidants due to activation of Nrf2 signaling via persulfidation of Keap1, the inhibitor protein of Nrf2. Hydropersulfides also inhibit ferroptosis...

mediates the degradation of NRF2; oxidative stress leads to conformational changes in KEAP1 that repress degradation of NRF2. O-GlcNAc modification of KEAP1...

Inhibition of mTORC1 was reported to increase transcription of NFE2L2 (NRF2) gene, which is a transcription factor that regulates the expression of electrophilic...

Ip C, Zhang Y, Park YM (January 2007). "Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology"...

P2 binding to ATP or ADP, presenting different signalling cascades. The Nrf2/ARE signalling pathway has a fundamental role at fighting against oxidative...

has been shown to interact with CIB1 and HNF1A. RAC3 also interacts with Nrf2 proteins. ETAR, ILK, and β-arr1 interact with RAC3 as well. RAC3 gene is...

1016/S0021-9258(18)54105-3. PMID 8380166. Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated...

ABCG2; NeuroD1; ASCL1/Mash1; Noggin; Beta-catenin; Notch-1; Notch-2; Brg1; Nrf2; N-Cadherin; Nucleostemin; Calcitonin R; Numb; CD15/Lewis X; Otx2; CDCP1;...

Mikami T, Murakami H, Tsujimoto Y (September 1999). "Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for...

grainyhead-like 3 (GRHL3), aryl hydrocarbon receptor nuclear translocator (ARNT) and NRF2. Volz, Armin; Korge, Bernhard P.; Compton, John G.; Ziegler, Andreas; Steinert...

does not reduce TNF production after LPS stimulation. It also activates the NRF2 antioxidant pathway and induces the expression of AhR target genes, unlike...

across the membrane.[citation needed] MCT1 can be upregulated by PPAR-α, Nrf2, and AMPK. Overexpression of MCT1 has been shown to increase the efficacy...

macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2". Circulation Research. 107 (6): 737–46. doi:10.1161/CIRCRESAHA.109.215715...

heat stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249 114411...

"Sulfhydryl-reactive phytochemicals as dual activators of transcription factors NRF2 and HSF1.". In Gang D (ed.). 50 Years of Phytochemistry Research. Vol. 43...

Iacobuzio-Donahue, C., Kern, S.E., Blair, I.A., Tuveson, D.A. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 475:106-109...

(2017). "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism". Aging Cell. 16 (3): 564–574. doi:10.1111/acel.12587...

alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy". International Journal of Biological Sciences. 17 (15): 4271–4284...

1016/S0304-3940(98)00569-2. PMID 9739985. S2CID 44836385. Venugopal R, Jaiswal AK (1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated...

essential for inflammation. Cynaropicrin is a potent activator of the ArH-Nrf2-Nqo1 pathway in human keratinocytes. It also inhibits the generation of ROS...

exposure to 3-MC. This causes the nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated response pathway to induce antioxidant responses. 3-MC is a ligand...

Rosen C, Keimes N, Liehn EA, Hölzle F, Kan YW, Pufe T, Sönmez TT, Wruck CJ. Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury...

"Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative...

gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol...

SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA (October 2003). "Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival"...

(May 2014). "The adjuvant component α-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its implication to...

Dudakov JA, Takahashi K, Shieh JH, Velardi E, Holland AM, et al. (2013). "Nrf2 regulates haematopoietic stem cell function". Nat Cell Biol. 15 (3): 309–16...

Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH (2015-01-01). "Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response...

aggressive forms of colorectal tumors. His lab also elucidated the role of Nrf2 in serine production in non-small cell lung cancer, with potential implications...

(May 2014). "The adjuvant component α-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its implication to...

Wang J (2014). "(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways". Annals of Clinical and Translational Neurology. 1 (4): 258–271...

nitric oxide synthase, mitogen-activated protein kinase, PPAR gamma, HIF1A, NRF2, ion channels, cystathionine beta synthase, and numerous other functionalities...

contribute to ALS. It has been observed that an increase in the expression of Nrf2, a transcription factor for system Xc-, leads to a protective effect in mice...

Yamamoto M, Hirohashi S (September 2008). "Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy". Proceedings...

mitochondrial biogenesis. It is known to co-activate nuclear respiratory factor 2 (NRF2/GABPA), and together with NRF-2 coactivates nuclear respiratory factor 1...

Autophagy, 7: 29–31. Fujita K, Xiao Q, Maeda D and Srinivasula SM. (2011). Nrf2-mediated induction of p62 controls TLR4-driven ALIS formation and autophagic...

4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer". ChemPlusChem. 83 (5): 320–333. doi:10.1002/cplu.201700539. ISSN 2192-6506...

2017). "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism". Aging Cell. 16 (3): 564–574. doi:10.1111/acel.12587...

falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic...

Chundi; Xiao, Wei (September 2022). "Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced...

the first step to synthesize N-acetylputrescine from putrescine. PMF1 and NRF2 work together to transcript the SAT1 gene. The SAT1 gene is 3,069 base pairs...

deacetylation of NLRP3, LKB1, and FOXO3a and restoration of AMPK-ACC/PGC-1α-Nrf2 signaling". International Immunopharmacology. 168 (Pt 2) 115852. doi:10.1016/j...

acid synthesis and live tumor formation and phosphorylating p62 to activate Nrf2-depdenent antioxidant responses. Furthermore, he discovered that gluconeogenic...

S2CID 8183469. Ren H, Han R, Liu X, Wang L, Koehler RC, Wang J (December 2021). "Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression,...

A. (2016). Curcumin inhibits PhIP-induced carcinogenicity by regulating Nrf2 and FOXO targets. Journal of Carcinogenesis & Mutagenesis, 6(236). Jain,...

(Aubagio), Monomethyl fumarate itself and its two precursors, which alters the NRF2 (nuclear factor erythroid 2(NF-E2)-related factor 2) transcription factor:...

Li H, Avraham S (Sep 2007). "The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells". Cancer Research...

oxidative stress, GSH depletion, and exposure to toxic chemicals, with the Nrf2, AP-1, and NF-κB transcription factors regulating the inducible and constitutive...

Yoshihisa (2015). "Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells". Free Radical Biology and Medicine. 79: 164–175...

during myocardial infarction via parallel activation of α-crystallin B and Nrf2". Journal of Cellular Physiology. 229 (9): 1272–82. doi:10.1002/jcp.24565...

Yang M, Yao Y, Eades G, Zhang Y, Zhou Q (October 2011). "MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism". Breast Cancer Research...