Simon was born in Louisiana, the descendant of slaves on both sides of her family, and is of ChoctawNative American heritage from her maternal great-grandmother. She began playing soccer at age 8 while still in Louisiana, then later attended high school and played travel team soccer in Fort Lauderdale, Florida.[4]
Simon went to college at Stetson University, where she also played soccer as a forward.[2][5] Simon described her career as a player as being "a referee's worst nightmare. ... If I made it through a game without a yellow card, it was a good day."[6] An assistant coach at Stetson was a referee assessor and recommended officiating to Simon as a way to remain engaged with soccer after graduation.[4]
On January 4, 2023, the United States Soccer Federation Referee Committee and FIFA re-appointed Simon to the 2023 FIFA Panel to officiate international matches.[14] That list included Alyssa Nichols, the second Black American woman to earn a FIFA badge, who viewed Simon as a role model.[15]
^Griffin, Tamerra (March 3, 2023). "FIFA referee Alyssa Nichols is aiming for the World Cup". Andscape. Retrieved May 10, 2023. Younger, Black, and Black women referees are trying to move up, and we tell them to reach out if they need help. For me, it was only Natalie who I was looking at, but for her, there was nobody else.