Neurological disorder

Nervous system
Nervous system
	Human nervous system
Identifiers
MeSH	D009422
	Anatomical terminology [edit on Wikidata]

Neurological disorder
Neurological disorder
	Neurons in person with epilepsy, 40x magnified
Specialty	Neurology

A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain, tauopathies, and altered levels of consciousness. There are many recognized neurological disorders, some are relatively common, but many are rare.

Interventions for neurological disorders include preventive measures, lifestyle changes, physiotherapy or other therapy, neurorehabilitation, pain management, medication, operations performed by neurosurgeons or a specific diet.^[1]^[2] The World Health Organization estimated in 2006 that neurological disorders and their sequelae (direct consequences) affect as many as one billion people worldwide, and identified health inequalities and social stigma/discrimination as major factors contributing to the associated disability and their impact.^[3]

Causes

Part of the causal chain leading to Alzheimer's disease

Although the brain and spinal cord are surrounded by tough membranes, enclosed in the bones of the skull and spinal vertebrae, and chemically isolated by the blood–brain barrier, they are very susceptible if compromised. Nerves tend to lie deep under the skin but can still become exposed to damage. Individual neurons, the neural circuits, and nerves into which they form are susceptible to electrochemical and structural disruption. Neuroregeneration may occur in the peripheral nervous system and thus overcome or work around injuries to some extents, but it is thought to be rare in the brain and spinal cord.^{[citation needed]}

The specific causes of neurological problems vary, but can include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems including pollution, malnutrition, brain damage, spinal cord injury, nerve injury or gluten sensitivity (with or without intestinal damage or digestive symptoms).^[2]^[4] Metal poisoning, where metals accumulate in the human body and disrupt biological processes, has been reported to induce neurological problems, at least in the case of lead.^[4] The neurological problem may start in another body system that interacts with the nervous system. For example, cerebrovascular disease involves brain injury due to problems with the blood vessels (cardiovascular system) supplying the brain; autoimmune disorders involve damage caused by the body's own immune system; lysosomal storage diseases such as Niemann–Pick disease can lead to neurological deterioration. The National Institute for Health and Care Excellence recommends considering the evaluation of an underlying coeliac disease in people with unexplained neurological symptoms, particularly peripheral neuropathy or ataxia.^[5]

In a substantial minority of cases of neurological symptoms, no neural cause can be identified using current testing procedures, and such "idiopathic" conditions can invite different theories about what is occurring.^{[citation needed]} Generally speaking, a substantial number of neurological disorders may have originated from a previous clinically not recognized viral infection. For example, it is thought that infection with the Hepatitis E virus, which is often initially asymptomatic may provoke neurological disorders,^[6] but there are many other examples as well.

Numerous examples have been described of neurological disorders that are associated with mutated DNA repair genes (for reviews see^[7]). Inadequate repair of DNA damages can lead directly to cell death and neuron depletion as well as disruptions in the pattern of epigenetic alterations required for normal neuronal function.^{[citation needed]}

DNA damage

Neurons are highly oxygenated cells and as a consequence DNA damage caused by chronic exposure to endogenous reactive oxygen species is a substantial challenge for neurons.^[8] Germline mutations deficient in the repair of DNA damages cause neuronal disfunction and are etiologically linked to many neurological disorders.^[8] For example, the neurological disorders, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia are linked to DNA damage accumulation and DNA repair deficiency.^[9]

Classification

Neurological disorders can be categorized according to the primary location affected, the primary type of dysfunction involved, or the primary type of cause. The broadest division is between central nervous system disorders and peripheral nervous system disorders. The Merck Manual lists brain, spinal cord and nerve disorders in the following overlapping categories:^[10]

Brain:
- Brain dysfunction according to type:
  - Apraxia (patterns or sequences of movements)
  - Agnosia (identifying things or people)
  - Amnesia (memory)
  - Aphasia (language)
  - Dysarthria (speech)
Spinal cord disorders (see spinal pathology, injury, inflammation)
Peripheral neuropathy and other Peripheral nervous system disorders
Cranial nerve disorder such as Trigeminal neuralgia
Autonomic nervous system disorders such as dysautonomia, multiple system atrophy
Seizure disorders such as epilepsy
Movement disorders of the central and peripheral nervous system such as Parkinson's disease, essential tremor, amyotrophic lateral sclerosis^{[failed verification]}, and Tourette's syndrome^{[failed verification]}
Multiple sclerosis and related disorders
Sleep disorders such as narcolepsy
Some speech disorders such as stuttering
Headaches, such as migraines, cluster headache, and tension headache
Pain (see back pain), such as complex regional pain syndrome and fibromyalgia
Delirium and dementia such as Alzheimer's disease
Coma and impaired consciousness, including stupor
Stroke (CVA, cerebrovascular attack)
Tumors of the nervous system (e.g. cancer)
Multiple sclerosis and other demyelinating diseases
Brain infections
Meningitis
Prion diseases (a type of infectious agent)

Many of the diseases and disorders listed above have neurosurgical treatments available, such as Tourette's syndrome, Parkinson's disease, essential tremor and obsessive compulsive disorder.

Neurological disorders in non-human animals are treated by veterinarians.^[11]^[12]

Mental functioning

A neurological examination can, to some extent, assess the impact of neurological damage and disease on brain function in terms of behavior, memory or cognition. Behavioral neurology specializes in this area. In addition, clinical neuropsychology uses neuropsychological assessment to precisely identify and track problems in mental functioning, usually after some sort of brain injury or neurological impairment.^{[citation needed]}

Alternatively, a condition might first be detected through the presence of abnormalities in mental functioning, and further assessment may indicate an underlying neurological disorder. There are sometimes unclear boundaries in the distinction between disorders treated within neurology, and mental disorders treated within the other medical specialty of psychiatry, or other mental health professions such as clinical psychology. In practice, cases may present as one type but be assessed as more appropriate to the other.^[13] Neuropsychiatry deals with mental disorders arising from specific identified diseases of the nervous system.^{[citation needed]}

One area that can be contested is in cases of idiopathic neurological symptoms - conditions where the cause cannot be established. It can be decided in some cases, perhaps by exclusion of any accepted diagnosis, that higher-level brain/mental activity is causing symptoms, rather than the symptoms originating in the area of the nervous system from which they may appear to originate. Classic examples are "functional" seizures, sensory numbness, "functional" limb weakness and functional neurological deficit ("functional" in this context is usually contrasted with the old term "organic disease"). Such cases may be contentiously interpreted as being "psychological" rather than "neurological". Some cases may be classified as mental disorders, for example as conversion disorder, if the symptoms appear to be causally linked to emotional states or responses to social stress or social contexts.^[14]

On the other hand, dissociation refers to partial or complete disruption of the integration of a person's conscious functioning, such that a person may feel detached from one's emotions, body and/or immediate surroundings. At one extreme this may be diagnosed as depersonalization derealization disorder. There are also conditions viewed as neurological where a person appears to consciously register neurological stimuli that cannot possibly be coming from the part of the nervous system to which they would normally be attributed, such as phantom pain or synesthesia, or where limbs act without conscious direction, as in alien hand syndrome. Theories and assumptions about consciousness, free will, moral responsibility and social stigma can play a part in this, whether from the perspective of the clinician or the patient.^{[citation needed]}

Conditions that are classed as mental disorders, or learning disabilities and forms of intellectual disability, are not themselves usually dealt with as neurological disorders. Biological psychiatry seeks to understand mental disorders in terms of their basis in the nervous system, however. In clinical practice, mental disorders are usually indicated by a mental state examination, or other type of structured interview or questionnaire process. At the present time, neuroimaging (brain scans) alone cannot accurately diagnose a mental disorder or tell the risk of developing one; however, it can be used to rule out other medical conditions such as a brain tumor.^[15] In research, neuroimaging and other neurological tests can show correlations between reported and observed mental difficulties and certain aspects of neural function or differences in brain structure. In general, numerous fields intersect to try to understand the basic processes involved in mental functioning, many of which are brought together in cognitive science. The distinction between neurological and mental disorders can be a matter of some debate, either in regard to specific facts about the cause of a condition or in regard to the general understanding of brain and mind.^{[citation needed]}

Moreover, the definition of disorder in medicine or psychology is sometimes contested in terms of what is considered abnormal, dysfunctional, harmful or unnatural in neurological, evolutionary, psychometric or social terms.^{[citation needed]}

References

^ KT, Thakur; E, Albanese; P, Giannakopoulos; N, Jette; M, Linde; MJ, Prince; TM, Steiner; T, Dua (14 March 2016). "Neurological Disorders". Mental, Neurological, and Substance Use Disorders: Disease Control Priorities, Third Edition (Volume 4). Chapter 5 Neurological Disorders. Washington (DC): Patel V, Chisholm D, Dua T, et al. pp. 87–107. doi:10.1596/978-1-4648-0426-7_ch5. ISBN 978-1-4648-0426-7. PMID 27227247.
^ ^a ^b Zis P, Hadjivassiliou M (26 February 2019). "Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease". Curr Treat Options Neurol (Review). 21 (3): 10. doi:10.1007/s11940-019-0552-7. PMID 30806821.
^ "WHO | Neurological Disorders: Public Health Challenges". March 14, 2007. Archived from the original on 14 March 2007.
^ ^a ^b Sanders, T.; Liu, Y.; Buchner, V.; Tchounwou, P. B. (2009). "Neurotoxic effects and biomarkers of lead exposure: A review". Reviews on Environmental Health. 24 (1): 15–45. doi:10.1515/reveh.2009.24.1.15. PMC 2858639. PMID 19476290.
^ "Coeliac disease: recognition, assessment and management. NICE guideline [NG20]". nice.org.uk. September 2015. Retrieved 18 September 2017.
^ Li Y, Peppelenbosch MP (April 2020). "Hepatitis E virus and neurological manifestations". Journal of the Neurological Sciences. 423: 117388. doi:10.1016/j.jns.2021.117388. PMID 33714454. S2CID 232133206.
^ Abugable, Arwa A.; Morris, Julia L.M.; Palminha, Nelma M.; Zaksauskaite, Ringaile; Ray, Swagat; El-Khamisy, Sherif F. (Sep 2019). "DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms". DNA Repair (Amst.). 81: 102669. doi:10.1016/j.dnarep.2019.102669. PMID 31331820.
^ ^a ^b Wang H, Dharmalingam P, Vasquez V, Mitra J, Boldogh I, Rao KS, Kent TA, Mitra S, Hegde ML. Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target? Mech Ageing Dev. 2017 Jan;161(Pt A):163-176. doi: 10.1016/j.mad.2016.09.005. Epub 2016 Sep 20. PMID 27663141; PMCID: PMC5316312
^ Wang H, Kodavati M, Britz GW, Hegde ML. DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication. Front Mol Neurosci. 2021 Dec 16;14:784361. doi: 10.3389/fnmol.2021.784361. PMID 34975400; PMCID: PMC8716463
^ Merck Manual: Brain, Spinal Cord and Nerve Disorders
^ "Veterinary Neurological Centre - Neurological Signs and Diseases". Archived from the original on 2016-11-02. Retrieved 2010-01-27.
^ "Merck Veterinary Manual". Merck Veterinary Manual.
^ Butler, C (1 March 2005). "Neurological syndromes which can be mistaken for psychiatric conditions". Journal of Neurology, Neurosurgery & Psychiatry. 76 (suppl_1): i31–i38. doi:10.1136/jnnp.2004.060459. PMC 1765684. PMID 15718219.
^ Roelofs, K.; Pasman, J. (2016). "Stress, childhood trauma, and cognitive functions in functional neurologic disorders". Handbook of Clinical Neurology. 139: 139–155. doi:10.1016/B978-0-12-801772-2.00013-8. ISBN 9780128017722. ISSN 0072-9752. PMID 27719835. S2CID 8534792.
^ "NIMH publications (2009) Neuroimaging and Mental Illness".