Nitrite reductase (NO-forming)

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nitrite reductase (NO-forming)
nitrite reductase (NO-forming)
	Nitrite reductase trimer, Alcaligenes faecalis
Identifiers
EC no.	1.7.2.1
CAS no.	37256-41-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

In enzymology, a nitrite reductase (NO-forming) (EC 1.7.2.1) is an enzyme that catalyzes the chemical reaction

nitric oxide + H₂O + ferricytochrome c ⇌ nitrite + ferrocytochrome c + 2 H⁺

The 3 substrates of this enzyme are nitric oxide, H₂O, and ferricytochrome c, whereas its 3 products are nitrite, ferrocytochrome c, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with a cytochrome as acceptor. The systematic name of this enzyme class is nitric-oxide:ferricytochrome-c oxidoreductase. Other names in common use include cd-cytochrome nitrite reductase, [nitrite reductase (cytochrome)] [misleading, see comments.], cytochrome c-551:O2, NO₂⁺ oxidoreductase, cytochrome cd, cytochrome cd1, hydroxylamine (acceptor) reductase, methyl viologen-nitrite reductase, nitrite reductase (cytochrome, and NO-forming). This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and Copper.

Structural studies

As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes 1RZP, 1RZQ, 1SJM, 1SNR, 1ZDQ, 1ZDS, 1ZV2, 2A3T, 2AVF, 2B08, 2BW4, 2BW5, 2BWD, 2BWI, 2DV6, 2DWS, 2DWT, 2DY2, 2FJS, and 2JFC.

References

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Williams PA, Fülöp V, Leung YC, Chan C, Moir JW, Howlett G, Ferguson SJ, Radford SE, Hajdu J (1995). "Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductase". Nat. Struct. Biol. 2 (11): 975–982. doi:10.1038/nsb1195-975. PMID 7583671. S2CID 21798842.
B, Kroneck PM; Vollack, KU; Zumft, WG; Eisenmann, E; Siddiqui, RA; Friedrich, B; Kroneck, PM (1996). "Characterization of the membranous denitrification enzymes nitrite reductase (cytochrome cd1) and copper-containing nitrous oxide reductase from Thiobacillus denitrificans". Arch. Microbiol. 165 (1): 55–61. doi:10.1007/s002030050296. PMID 8639023. S2CID 12737971.
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