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prolonged expression of Oct4 in snake embryos compared to mouse embryos. Mouse embryos that have received an extra, transgenic dose of Oct4 also show lengthening...

reinforcing the specification of the ICM and the TE in early mouse embryos. Oct4: Oct4 is expressed in the ICM and participate in maintaining its pluripotency...

pluripotent cells. Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent...

involved in cell proliferation, individually forms complexes with Sox2, Oct4 and Nanog in embryonic stem cells. These three pluripotency factors contribute...

showed in 2006 that the introduction of four specific genes (named c-Myc, Oct4, Sox2 and KLF4), collectively known as Yamanaka factors, encoding transcription...

iPSCs. Oct4 is part of the core regulatory genes needed for pluripotency, as it is seen in both embryonic stem cells and tumors. The use of Oct4 even in...

Teratomas Yes Yes Pluripotency factors Oct4, Nanog, Sox2 (high levels), Klf2, Klf4 Oct4, Nanog, Sox2 (low levels) Sox2/Oct4 dimerization High Low Naive markers...

embryo, but could in the end reduce it to four transcription factors – Sox2, Oct4, Klf4 and c-Myc. The 2012 Nobel Prize in Physiology or Medicine was awarded...

pioneered in 2006 using mouse fibroblasts and four transcription factors, Oct4, Sox2, Klf4 and c-Myc; this technique, called reprogramming, later earned...

List: Human dermal fibroblasts → multilineage blood progenitors (Oct4 and cytokine treatment) Mouse dermal fibroblasts → polygonal hyaline chondrogenic...

2020, Sinclair's group published that three Yamanaka transcription factors, Oct4, Sox2, and Klf4, when delivered together in a virus, could safely reverse...

FB, Assumpção JG, De Mello MP, Maciel-Guerra AT, et al. (December 2011). "OCT4 immunohistochemistry may be necessary to identify the real risk of gonadal...

layer differentiation is controlled by two transcription factors: Sox2 and Oct4 proteins. These transcription factors cause the pluripotent mouse embryonic...

[citation needed] Pluripotent stem cells express transcription factors Nanog, Oct4 and Sox2 that seem to play a role in repressing Xist. In the absence of Tsix...

OCTA, E4F1 and MED24 in hESCs. As OCT4 is involved in the core transcriptional circuitry in hESCs, misregulation of OCT4 induces cell differentiation. PRDM14...

morphology as well as gene expression, including canonical pluripotency markers Oct4, Sox2, and Nanog. Adult stem cell treatments have been successfully used...

in human embryos in Nature, demonstrating that the transcription factor Oct4 is essential for fetal development. In addition to her research, Niakan has...

factors. The field gained significant interest once four transcription factors Oct4/Sox2/cMyc/Klf4 were found to reprogram cells from a differentiated state...

Interspecific Cloning and Embryo Aggregation Influence the Expression of oct4, nanog, dox2, and cdx2 in Cheetah and Domestic Cat Blastocysts". [Abstract]...

"non-canonical" microRNA targets in the coding regions of the mouse Nanog, Oct4 and Sox2. Most of these targets are not conserved in the human orthologues...

FOXO1 regulates critical pluripotency associated genes such as OCT4, NANOG and SOX2 (Oct4 and Sox2 are Yamanaka factors) by occupying and activating their...

Thomson, James A.; Kosik, Kenneth S. (15 May 2009). "MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells"...

homeodomain protein, Cdx2. This transcription factor represses the expression of Oct4 and Nanog transcription factors in the trophoblast. These genomic alterations...

Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways". Molecules. 28 (14). January 2023. ISSN 1420-3049. Archived...

the essential stem cell factor, octamer-binding transcription factor 4 (Oct4), in two separate unbiased mass spectrometry (spec) screens Sall4 can also...

"Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes". Genes & Development. 25 (9): 946–958. doi:10.1101/gad.615211...

Müller M, Engers R, Schulz WA (2007). "Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies". Biochem. Pharmacol. 72 (11): 1577–88...

these cells have similar pluripotent characteristics. Pluripotency factors Oct4 and Nanog play a role in transcriptionally regulating the embryonic stem...

demonstrating that AAV2-induced transient expression of the reprogramming genes Oct4, Sox2, and Klf4 (OSK) could reverse retinal aging and restore visual function...

zebrafish, the homeodomain protein Pou5f3 (a paralog of mammalian POU5F1 (OCT4) has an analogous role. Without the function of these proteins MBT gene expression...

evidence of the role of NF-kB in innate immunity, and co-discovering the Oct4 nuclear factor with Louis M. Staudt, among other contributions. Following...

encourage cells to return to a 'stem-like' state alongside transcription factors Oct4, Sox2 and Klf4. It has since been shown that it is possible to generate iPSCs...

as somatic cell reprogramming, can be achieved by ectopic expression of Oct4, Klf4, Sox2, and c-Myc (OKSM). Upon induction, mouse fibroblasts must undergo...

medulloblastoma cells can be reprogrammed successfully by JDP2 and the defined factor OCT4 to become induced pluripotent stem cells (iPSC)-like cells. This iPSC-like...

neural-derived cells. Moreover, M-Ras plays a crucial role in the downregulation of OCT4 and NANOG protein levels upon differentiation and has been demonstrated to...

using an Oct4-GFP transgene. On average only 25% of cells survived the acid treatment, but over 50% of those that survived converted to Oct4-GFP+CD45−...

custom viral infection (OSKM) strategy. Expression of miR367 is essential for Oct4 expression and miR302/367-mediated reprogramming. MicroRNA 1. 2. 3. 4. 5...

of tasks. 7 December A gene therapy based on three transcription factors, Oct4, Sox2, and Klf4 (OSK), is shown to provide sustained vision recovery in mice...

expression level of the Oct4 gene decreasing with embryonic stem cell differentiation. Lee et al. performed a ChIP analysis of the Oct4 promoter, associated...

self-renewal, as it methylates H3R17 and H3R26 at core pluripotency genes such as Oct4, SOX2, and Nanog. It is possible that H3R26me2 levels are changed before...

YJ, Yang H, He ZL (Nov 2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]". Zhonghua Bing Li Xue Za Zhi Chinese...

UTC−05:00 Mar-Nov MEK GMFM Bassatine Air Base Meknes, Morocco UTC±00:00 Mar-Oct4 MEL YMML Melbourne Airport Melbourne, Victoria, Australia UTC+10:00 Oct-Apr...

body in Fossiomanus may have been the result of a change in the GDF11 or OCT4 genes, which regulate the development of the transition from the trunk to...

Lukas; Schübeler, Dirk; Thomä, Nicolas H. (26 June 2020). "Mechanisms of OCT4-SOX2 motif readout on nucleosomes". Science. 368 (6498): 1460–1465. Bibcode:2020Sci...

into induced pluripotent stem cells by the treatment of only two factors - Oct4 and Sox2. List of human cell types derived from the germ layers Brodie, J...

DL; Yanagimachi, R; Page, DC; Jaenisch, R. "Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei" Development, 130...

are first transfected with pluripotent reprogramming factors temporarily (Oct4, Sox2, Nanog, etc.) before being transfected with the desired inhibitory...

undifferentiated embryonic state, which relies on the transcription factors Oct4, Sox2, Myc, and Klf4. cellular senescence centimorgan (cM) A unit for measuring...

expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for...

expression vector. This retroviral expression of four transcriptional factors (Oct4, Sox2, Klf4 and c-Myc; OSKM) induces pluripotency in somatic cells. This...

progression. In mouse embryonic stem cells, Suv39h1 expression is repressed by OCT4 protein through the induction of an antisense long non-coding RNA. SUV39H1...

can be tested. Two markers that are present during pluripotent stages are OCT4 and NANOG. These two markers are diminished during the course of development...

TC, Jin J, Casey ES (February 2011). "Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis". Developmental Biology. 350 (2): 429–440. doi:10...

Samantha Z Yammine, Cindi M Morshead, Derek van der Kooy. 2017. Quiescent Oct4 + Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein...

the introduction of the Yamanaka factors, Oct4, Sox2, c-Myc, and KLF4. While not as frequently studied as Oct4 and Sox2, KLF4 has become of interest in...

upregulated and depends on the presence of a transcriptional regulator, OCT4. OCT4 serves a positive regulator of MIAT transcription and as of now is the...

development-related binding sites, such as pluripotent stem cell related factors (Oct4, Sox2, Nanog), sex-determining HMG box factors, and various homeobox/homeodomain...

Leal, Francisca; Nóvoa, Ana; Cohn, Martin J.; Mallo, Moisés (August 2016). "Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity". Developmental Cell...

alkaline phosphatase (PLAP), vimentin, actin, desmin, alpha fetoprotein (AFP), OCT4, human chorionic gonadotropin (hCG), and carcinoembryonic antigen (CEA))...

Hamanishi J, Matsumura N, Baba T, Horiuchi A, et al. (December 2010). "Oct4 expression in immature teratoma of the ovary: relevance to histologic grade...

P.; Hou, Y.; MacCarthy, C. M.; Wu, G.; Schöler, H. R. (2019). "Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs". Cell...

A, Voet T, Marioni JC, Zernicka-Goetz M (March 2016). "Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos". Cell. 165 (1):...

[KLF4] is one of the so-called magic four transcription factors, KLF4, Oct4, SOX2 and MYC. KLF5, like KLF3, is important in adipocytes and KLF6 is an...

and found significant participation of major pluripotency factors such as OCT4, NANOG, and SOX2 in the interaction network during somatic cell reprogramming...

Grubisic, Ivan; Tjian, Robert (2011). "A DNA Repair Complex Functions as an Oct4/Sox2 Coactivator in Embryonic Stem Cells". Cell. 147 (1). Elsevier BV: 120–131...

decisions. They investigated whether fluctuations in the expression levels of OCT4 and SOX2, two master regulators of pluripotency, impact the differentiation...

Lee KC, He X, et al. (April 2014). "Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors". Nucleic Acids...

in some cell types. SYMPK has been shown to interact with CSTF2, HSF1 and Oct4 GRCh38: Ensembl release 89: ENSG00000125755 – Ensembl, May 2017 GRCm38: Ensembl...

article has been cited 197times Morrison GM, Brickman JM. Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development...

Dubois A, Heurtier V, Fischer V, Gonzalez I, Chervova A, et al. (July 2022). "OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine...

Trotter; Yoshihiro Komatsu; Yuji Mishina; Trevor K Archer (October 2008). "Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells"....

stem cells. In humans it is under the direct regulation of POU5F1 (a.k.a. OCT4) and NANOG. Through autocrine and paracrine signalling, endogenous Elabela...

expression of EMT-related genes (i.e., Snail1, N-cadherin, ABCG2, Nanog and Oct4), enhanced expression of E-cadherin and inhibition of survival signalling...

by transducing cells using retroviruses to encode such stem cell genes as Oct4, Sox2, KLF4 and cMYC. This allows for skin cells to be reprogrammed into...

N, Désilets S, Nury D, Cowan C, Pucéat M (September 2009). "Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying...

of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4". Biochemical and Biophysical Research Communications. 500 (2): 302–309....

and a large fraction of the genome after fertilization: maternal Nanog, Oct4 and SoxB1. Some of these factors are involved in stem cell maintenance and...

2009; 19:816-26 (2009). [1] Ding et al. A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity...

pluripotency. This function is probably mediated through direct control by FOXO1 of OCT4 and SOX2 gene expression through occupation and activation of their respective...

Wang, Jiahong; Chen, Nannan; Yan, Jian; Pan, Xin (2017-01-12). "HIF-2α and Oct4 have synergistic effects on survival and myocardial repair of very small...

et al. (May 2005). "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and...

structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers". Genes & Development. 17 (16): 2048–2059. doi:10...

cell development by activating pluripotent genes through interacting with Oct4 and recruiting P-TEFb (positive transcription elongation factor). By occupying...

identified using markers common to embryonic stem cells such as nuclear Oct4, CD34, vimentin, alkaline phosphatase, stem cell factor and c-Kit. However...

Gérard, Matthieu (November 2024). "cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers". Nature Structural &...

Bertero A, Turner JM, Niakan KK (Oct 2017). "Genome editing reveals a role for OCT4 in human embryogenesis". Nature. 550 (7674): 67–73. Bibcode:2017Natur.550...

Marques-de-Faria AP, D'Souza-Li LF, Lemos-Marini SH, Guerra G (December 2011). "OCT4 immunohistochemistry may be necessary to identify the real risk of gonadal...

survival and metastasis by regulation of target genes as VEGF, GLUT-1, ADAM-1, Oct4 and Notch. Hypoxia plays an important role in the regulation of cancer stem...

Xu K, Chen X, Jiang Y, et al. (March 2015). "The combination of Tet1 with Oct4 generates high-quality mouse-induced pluripotent stem cells". Stem Cells...

and 4) RAD21 co-localization with CTCF-independent pluripotency factors (Oct4, Nanog, Sox4, and KLF2). RAD21 cooperates with CTCF, tissue-specific transcription...

Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS (May 2009). "MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells"...

enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4". Cell Reports. 6 (5): 951–60. doi:10.1016/j.celrep.2014.01.038. PMC 4004339...

that, in cultured stem cells activation of stem cell transcription factor OCT4 pathway upregulated JADE1 gene expression along with stem cell factors NANOG...

have shown that Tbx3 is an important factor that, together with KLF4, SOX2, OCT4, Nanog, LIN-28A and C-MYC, can reprogram somatic cells to form iPS cells...

Zhang J, Thomson AM, Lim B, Rigoutsos I (October 2008). "MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation". Nature...

self-renewal, as it methylates H3R17 and H3R26 at core pluripotency genes such as Oct4, Sox2, and Nanog. CARM1-mediated methylation of H3R17 is needed to establish...

food. Researchers at the University of Virginia Health System find that the Oct4 gene, once thought to be inactive in adults, actually plays a vital role...

Y, Zhang J, Thomson AM, Lim B, Rigoutsos I (2008). "MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation". Nature...