ODAD3

ODAD3
Identifiers
AliasesODAD3, CILD30, coiled-coil domain containing 151, ODA10, CCDC151, outer dynein arm docking complex subunit 3
External IDsOMIM: 615956; MGI: 1924859; GeneCards: ODAD3
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

115948

77609

Ensembl

ENSG00000198003

ENSMUSG00000039632

UniProt

A5D8V7

Q8BSN3

RefSeq (mRNA)

NM_145045
NM_001302453
NM_001302454

NM_001163787
NM_029939

RefSeq (protein)

NP_001289382
NP_001289383
NP_659482

NP_001157259
NP_084215

Location (UCSC)Chr 19: 11.42 – 11.44 MbChr 9: 21.9 – 21.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Outer dynein arm-docking complex subunit 3 is a protein that in humans is encoded by the ODAD3 gene (previously CCDC151).[5] As its name suggests, ODAD3 is part of a protein complex called the "dynein arm-docking complex" (ODA-DC), which is involved in outer dynein arm assembly.[6]

Clinical significance

Mutations in the gene ODAD3 are associated with Primary ciliary dyskinesia.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198003 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039632 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Coiled-coil domain containing 151".
  6. ^ "Outer dynein arm-docking complex subunit 3". uniprot.org. UniProt consortium. Retrieved 2026-08-14.
  7. ^ Alsaadi MM, Erzurumluoglu AM, Rodriguez S, Guthrie PA, Gaunt TR, Omar HZ, Mubarak M, Alharbi KK, Al-Rikabi AC, Day IN (December 2014). "Nonsense mutation in coiled-coil domain containing 151 gene (CCDC151) causes primary ciliary dyskinesia". Human Mutation. 35 (12): 1446–8. doi:10.1002/humu.22698. PMC 4489323. PMID 25224326.

Further reading

  • Jerber J, Baas D, Soulavie F, Chhin B, Cortier E, Vesque C, Thomas J, Durand B (February 2014). "The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals". Human Molecular Genetics. 23 (3): 563–77. doi:10.1093/hmg/ddt445. PMID 24067530.
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