PALS2

PALS2
Identifiers
AliasesPALS2, VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T
External IDsOMIM: 606959; MGI: 1927340; GeneCards: PALS2
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

51678

56524

Ensembl

ENSG00000105926

ENSMUSG00000038388

UniProt

Q9NZW5

Q9JLB0

RefSeq (mRNA)

NM_001303037
NM_016447

RefSeq (protein)

NP_001289966
NP_057531

NP_001158205
NP_001158206
NP_064323
NP_001348176
NP_001348177

Location (UCSC)Chr 7: 24.57 – 24.69 MbChr 6: 50.09 – 50.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein PALS2 is a protein that in humans is encoded by the PALS2 gene (previously MPP6).[5][6][7]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1), ZO1-like (see TJP1), p55-like (see MPP1), and LIN2-like (see CASK), based on their size and the presence of additional domains. PALS2/MPP6 is a member of the p55-like MAGUK subfamily.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105926 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038388 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
  6. ^ Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
  7. ^ a b "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".

Further reading


Stub icon

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.