PARP4

PARP4
Identifiers
AliasesPARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193, poly(ADP-ribose) polymerase family member 4
External IDsOMIM: 607519; MGI: 2685589; GeneCards: PARP4
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

143

328417

Ensembl

ENSG00000102699

ENSMUSG00000054509

UniProt

Q9UKK3

E9PYK3

RefSeq (mRNA)

NM_006437

NM_001145978

RefSeq (protein)

NP_006428

NP_001139450

Location (UCSC)Chr 13: 24.42 – 24.51 MbChr 14: 56.81 – 56.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.[5][6]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.[6]

Interactions

PARP4 has been shown to interact with Major vault protein.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102699 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054509 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Still IH, Vince P, Cowell JK (Mar 2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.
  6. ^ a b "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4".
  7. ^ van Zon A, Mossink Marieke H, Schoester Martijn, Scheffer George L, Scheper Rik J, Sonneveld Pieter, Wiemer Erik A C (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821.
  8. ^ Kickhoefer VA, Siva A C, Kedersha N L, Inman E M, Ruland C, Streuli M, Rome L H (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748.

Further reading

Stub icon

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.