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PARVB
Identifiers
Aliases	PARVB, CGI-56, parvin beta
External IDs	OMIM: 608121; MGI: 2153063; GeneCards: PARVB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EDL, 4EDM, 4EDN
Gene location (Human)
Chr.	Chromosome 22 (human)
End	44,172,939 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	84,199,889 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; monocyte; ; left ventricle; ; right auricle of heart; ; islet of Langerhans; ; right lung; ; right adrenal gland; ; upper lobe of left lung;
	Top expressed in
	blood; ; lumbar spinal ganglion; ; muscle of thigh; ; molar; ; right lobe of liver; ; extraocular muscle; ; soleus muscle; ; digastric muscle; ; atrium; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding;
Cellular component	cytoplasm; cytosol; cell junction; plasma membrane; cell projection; sarcomere; Z discdkac; cytoskeleton; membrane; focal adhesion; lamellipodium; actin cytoskeleton;
Biological process	actin cytoskeleton reorganization; cell adhesion; cell projection assembly; lamellipodium assembly; establishment or maintenance of cell polarity regulating cell shape; establishment or maintenance of cell polarity; substrate adhesion-dependent cell spreading;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29780
	170736
	ENSG00000188677
	ENSMUSG00000022438
	Q9HBI1
	Q9ES46
	NM_001003828; NM_001243385; NM_001243386; NM_013327
	NM_133167
	NP_001003828; NP_001230314; NP_001230315; NP_037459
	NP_573395
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-parvin is a protein that in humans is encoded by the PARVB gene.^[5]^[6]^[7]

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188677 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022438 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
^ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID 11171322.
^ ^a ^b "Entrez Gene: PARVB parvin, beta".

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction". J. Cell Biol. 153 (6): 1251–64. doi:10.1083/jcb.153.6.1251. PMC 2192033. PMID 11402068.
Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID 11722847.
Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. doi:10.1016/S0006-291X(02)02381-1. PMID 12372433.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor". Genes Cells. 9 (3): 193–204. doi:10.1111/j.1356-9597.2004.00717.x. PMID 15005707.
Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction". J. Cell Biol. 165 (4): 539–51. doi:10.1083/jcb.200308141. PMC 2172344. PMID 15159419.
Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival". J. Biol. Chem. 279 (40): 41695–705. doi:10.1074/jbc.M401563200. PMID 15284246.
Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer". Oncogene. 23 (55): 8959–70. doi:10.1038/sj.onc.1208112. PMID 15467740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. doi:10.1093/jnen/64.4.334. PMID 15835269.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188677 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022438 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[pmid11171322-6] Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID 11171322.

[entrez-7] "Entrez Gene: PARVB parvin, beta".

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PARVB

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