PCNA-associated factor

PCLAF
Identifiers
AliasesPCLAF, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, KIAA0101, PCNA clamp associated factor
External IDsOMIM: 610696; MGI: 1915276; GeneCards: PCLAF
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9768

68026

Ensembl

ENSG00000166803

ENSMUSG00000040204

UniProt

Q15004

Q9CQX4

RefSeq (mRNA)

NM_001029989
NM_014736

NM_026515

RefSeq (protein)

NP_001025160
NP_055551

NP_080791

Location (UCSC)Chr 15: 64.36 – 64.39 MbChr 9: 65.8 – 65.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PCNA-associated factor (also called “PCNA clamp associated factor”) is a protein that in humans is encoded by the PCLAF gene (previously KIAA0101).[5][6][7] The PCLAF protein binds to PCNA and regulates DNA repair during DNA replication.[8]

Interactions

PCLAF has been shown to interact with PCNA.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.
  6. ^ Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.
  7. ^ "Entrez Gene: KIAA0101 KIAA0101".
  8. ^ "Q15004 · PAF15_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

Further reading

Stub icon

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.