PDS5B

PDS5B
Identifiers
AliasesPDS5B, APRIN, AS3, CG008, PDS5 cohesin associated factor B
External IDsOMIM: 605333; MGI: 2140945; GeneCards: PDS5B
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

23047

100710

Ensembl

ENSG00000083642

ENSMUSG00000034021

UniProt

Q9NTI5

Q4VA53

RefSeq (mRNA)

NM_015032
NM_015928

NM_175310
NM_001346503

RefSeq (protein)

NP_055847

NP_001333432
NP_780519

Location (UCSC)Chr 13: 32.59 – 32.78 MbChr 5: 150.6 – 150.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein that in humans is encoded by the PDS5B gene.[5][6][7] It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083642 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034021 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J, et al. (Feb 1997). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99. doi:10.1006/geno.1996.0428. PMID 8812419.
  6. ^ Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM (May 1999). "Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus". J Steroid Biochem Mol Biol. 68 (1–2): 41–50. doi:10.1016/S0960-0760(98)00165-4. PMID 10215036. S2CID 32542980.
  7. ^ "Entrez Gene: APRIN androgen-induced proliferation inhibitor".


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