Kayla Harrison, the only two-time Olympic gold medalist in judo in the history of the United States, entered her second PFL playoffs unbeaten in 10 pro bouts. She faced Genah Fabian who held a 4-1 record and had won both of her PFL regular season bouts against Julija Pajic and Laura Sanchez to advance to the playoffs. This is the second time that Harrison and Fabian had been scheduled to fight in the PFL. They were set to meet in the 2019 semifinals in October of that year, but Fabian withdrew due to an illness after issues with her weight cut.[2]
The other lightweight semifinal was expected to feature 2019 finalist Larissa Pacheco and former Invicta FC fighter Taylor Guardado.[3] However, at the weigh-ins, Larissa Pacheco missed weight by 2 pounds and therefore was removed from the tournament and was replaced by 5th seeded Mariana Morais. Morais's original opponent, Claudia Zamora, instead faced Marina Mokhnatkina after Kaitlin Young, Marina's opponent, was removed from the card.[4]
The heavyweight playoffs also began. Top seed Bruno Cappelozza took on Jamelle Jones, who qualified for the playoffs with a knockout of Klidson Abreu after stepping in as an alternate. Denis Goltsov and Ante Delija also met in the other heavyweight semifinal.[5][6]
* Larissa Pacheco was originally scheduled to face Taylor Guardado but was unable to continue in the tournament. She was replaced by #5 ranked Mariana Morais.