Search Results: PIKfyve
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PIKFYVE
Rabu, 2026-06-17 13:16:15PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene. PIKFYVE belongs to a large family...
Click to read more »Apilimod
Jumat, 2026-01-02 02:38:39additional mode of action, as an inhibitor of the lipid kinase enzyme PIKfyve. PIKfyve makes two lipids, PtdIns5P and PtdIns(3,5)P2, whose syntheses are efficiently...
Click to read more »Phosphatidylinositol 3,5-bisphosphate
Minggu, 2025-06-08 21:44:47PIKfyve, called ArPIKfyve/VAC14, that scaffolds a ternary regulatory complex, known as the PAS complex (from the first letters of PIKfyve/ArPIKfyve/Sac3)...
Click to read more »Fig4
Senin, 2026-08-10 13:19:21hetero-oligomer with ArPIKfyve (gene symbol, VAC14) and this binary complex associates with the phosphoinositide kinase PIKFYVE in a ternary PAS complex...
Click to read more »VAC14
Senin, 2026-06-01 12:29:38Protein VAC14 homolog, also known as ArPIKfyve (Associated Regulator of PIKfyve), is a protein that in humans is encoded by the VAC14 gene. The content...
Click to read more »Phosphatidylinositol 5-phosphate
Kamis, 2026-06-25 00:54:16heterologous overexpression of the enzymatically inactive PIKfyve point-mutant (PIKfyveK1831E) and PIKfyve silencing by small interfering RNAs. Such a role is...
Click to read more »Phosphatidylinositol 3-phosphate
Kamis, 2024-06-06 23:20:19inositol ring, and can be converted to PtdIns(3,5)P2 by the lipid kinase PIKfyve. Both FYVE domains and PX domains – found in proteins such as SNX1, HGS...
Click to read more »Salmonella
Selasa, 2026-08-11 08:47:39Stow JL, Teasdale RD (April 2010). "Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella". The EMBO Journal. 29...
Click to read more »List of human protein-coding genes 6
Senin, 2025-11-03 07:57:2212166 PIK3R5 HGNC:30035; Q8WYR1 12167 PIK3R6 HGNC:27101; Q5UE93 12168 PIKFYVE HGNC:23785; Q9Y2I7 12169 PILRA HGNC:20396; Q9UKJ1 12170 PILRB HGNC:18297;...
Click to read more »FYVE domain
Jumat, 2025-09-19 23:45:11named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been...
Click to read more »Arul Chinnaiyan
Jumat, 2026-07-31 22:34:45and NSD2 methyltransferase. His team has also defined the lipid kinase PIKfyve as a therapeutic target in multiple malignancies, including prostate cancer...
Click to read more »Anaplastic lymphoma kinase
Sabtu, 2026-08-22 23:35:40CDKN1B(p27Kip1), cyclin D2, NIPA, RAC1, CDC42, BCAR1(p130Cas), SHP1, and PIKFYVE. Phosphorylated ALK activates multiple downstream signal transduction pathways...
Click to read more »Fleck corneal dystrophy
Rabu, 2025-11-12 21:55:22dystrophy, is a rare form of corneal dystrophy. It is caused by mutations in PIKFYVE gene. Small opacities, some of which resemble "flecks", are scattered in...
Click to read more »Yunis–Varon syndrome
Selasa, 2026-08-11 19:48:54progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex". The Journal of Biological Chemistry. 282 (33): 23878–91....
Click to read more »SGK1
Selasa, 2026-02-24 06:07:42delayed rectifier potassium current through this channel by phosphorylating PIKfyve, which then makes PI(3,5)P2, which goes on to increase the RAB11-dependent...
Click to read more »RABEPK
Jumat, 2026-02-27 12:23:25Jason; Soans Aleric; Finley Russell L; Shisheva Assia (Dec 2003). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi...
Click to read more »Macropinosome
Sabtu, 2025-10-18 22:32:29Stow, J. L.; Teasdale, R. D. (2010). "Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella". The EMBO Journal. 29...
Click to read more »Unfolded protein response
Jumat, 2026-05-15 17:16:35E, Herrmann U, Losa M, Marpakwar R, et al. (September 2021). "Loss of PIKfyve drives the spongiform degeneration in prion diseases". EMBO Molecular Medicine...
Click to read more »TRPV6
Minggu, 2026-08-16 09:48:58TRPV6 expression by enhancing phosphatidylinositol-3-phosphate-5-kinase PIKfyve (PIP5K3). This kinase is critical for the generation of secondary messenger...
Click to read more »List of OMIM disorder codes
Selasa, 2026-08-04 21:22:31perceptive deafness; 217400; SLC4A11 Corneal fleck dystrophy; 121850; PIKFYVE Cornelia de Lange syndrome 1; 122470; NIPBL Cornelia de Lange syndrome...
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