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PPIL1
Identifiers
Aliases	PPIL1, CYPL1, PPIase, hCyPX, CGI-124, peptidylprolyl isomerase like 1, PCH14
External IDs	OMIM: 601301; MGI: 1916066; GeneCards: PPIL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XWN, 2K7N, 2X7K
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,874,803 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,483,160 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; oocyte; ; gonad; ; cardiac muscle tissue of right atrium; ; secondary oocyte; ; right auricle of heart; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	embryo; ; ventricular zone; ; superior cervical ganglion; ; morula; ; embryo; ; neural tube; ; blastocyst; ; epiblast; ; yolk sac; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	isomerase activity; protein binding; disordered domain specific binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleoplasm; nucleus; U2-type catalytic step 2 spliceosome;
Biological process	mRNA processing; protein folding; RNA splicing; mRNA splicing, via spliceosome; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51645
	68816
	ENSG00000137168
	ENSMUSG00000024007
	Q9Y3C6
	Q9D0W5
	NM_016059
	NM_026845
	NP_057143
	NP_081121
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.^[5]^[6]^[7]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.

Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137168 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024007 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mann SS, Pettenati MJ, von Kap-herr C, Hart TC (Mar 1999). "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 228–9. doi:10.1159/000015186. PMID 10072585. S2CID 85413695.
^ Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S (Jan 1997). "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. 72 (2–3): 242–5. doi:10.1159/000134199. PMID 8978786.
^ ^a ^b "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1".

Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Xu C, Xu Y, Tang Y, et al. (2005). "Backbone and side chain assignments of human Peptidylprolyl Isomerase Like 1 (hPPIL1)". J. Biomol. NMR. 31 (2): 179–80. doi:10.1007/s10858-004-8238-0. PMID 15772761. S2CID 30456850.
Xu C, Zhang J, Huang X, et al. (2006). "Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP". J. Biol. Chem. 281 (23): 15900–8. doi:10.1074/jbc.M511155200. PMID 16595688.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137168 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024007 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072585-5] Mann SS, Pettenati MJ, von Kap-herr C, Hart TC (Mar 1999). "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 228–9. doi:10.1159/000015186. PMID 10072585. S2CID 85413695.

[pmid8978786-6] Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S (Jan 1997). "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. 72 (2–3): 242–5. doi:10.1159/000134199. PMID 8978786.

[entrez-7] "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1".

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PPIL1

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