PPIL3

PPIL3
Identifiers
AliasesPPIL3, CYPJ, peptidylprolyl isomerase like 3
External IDsOMIM: 615811; MGI: 1917475; GeneCards: PPIL3
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
5.2.1.8↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

53938

70225

Ensembl

ENSG00000240344

ENSMUSG00000026035

UniProt

Q9H2H8

Q9D6L8

RefSeq (mRNA)

NM_032472
NM_130906
NM_131916

NM_001285826
NM_001285827
NM_027351
NM_027374

RefSeq (protein)

NP_115861
NP_570981

NP_001272755
NP_001272756
NP_081627
NP_081650

Location (UCSC)Chr 2: 200.87 – 200.89 MbChr 1: 58.47 – 58.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene.[5][6]

Function

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; some of these variants encode different isoforms.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240344 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026035 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y (Jul 2001). "Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3–4): 231–6. doi:10.1159/000056909. PMID 11435694. S2CID 713529.
  6. ^ a b "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3".

Further reading


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