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housekeeping functions. In humans it is encoded by the gene designated as PRKDC or XRCC7. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related...

the Navajo and Apache population causes SCID and radiation intolerance. PRKDC or DNA-PKcs is a gene required for DNA repair and V(D)J recombination. First...

C57BL/Ka and BALB/c mice, featuring a loss of function mutation in the PRKDC gene. The PRKDC gene product is necessary for resolving breaks in DNA strands during...

laboratory rat models were created in 2022, one having Prkdc knocked out, the other having both Prkdc and Rag2 knocked out. Severe combined immunodeficiency...

and many other phenomena. In 2019 researchers published a crossing of a prkdc-/- and a IL2rga-/- strain that produced transparent, immunodeficient offspring...

mutation in the gene for protein kinase, DNA activated, catalytic polypeptide (PRKDC), which plays a role in repairing double-stranded DNA breaks. This has implications...

endonuclease activity on 5' and 3' overhangs and hairpins when complexed with PRKDC. Artemis plays an essential role in V(D)J recombination, the process by...

ataxia-telangiectasia mutated response to DNA damage ATR ataxia- and Rad3-related " PRKDC DNA-dependent protein kinase catalytic subunit (DNA-PKcs) " MTOR mammalian...

multiple mtDNA deletion disorders. MPV17 has been shown to interact with Prkdc protein during Adriamycin-induced nephropathy in mice. Navajo neurohepatopathy...

Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A (2015) PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent...

Prkdcscid is a loss-of-function mutation in the mouse homologue of the human PRKDC gene, which encodes a protein that resolves DNA strand breaks that occur...

xenografts in the immunodeficient NSG host strain (aka, NOD scid gamma; NOD.Cg-Prkdc<scid> Il2rg<tm1>Wjl/SzJ) mice developed at The Jackson Laboratory. MMHCdb...

gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand...

functional T and B cells that is derived from a mutation of protein kinase (Prkdc: protein kinase, DNA activated, catalytic polypeptide), which is the causative...

FANCA, IKBKG IKK2, IRAK1, MAP3K14, MAP3K7, MAP3K8, NFKBIA, NCOA3, PPM1B, PRKDC, and TRAF2. GRCh38: Ensembl release 89: ENSG00000213341 – Ensembl, May 2017...

Q15139 12834 PRKD2 HGNC:17293; Q9BZL6 12835 PRKD3 HGNC:9408; O94806 12836 PRKDC HGNC:9413; P78527 12837 PRKG1 HGNC:9414; Q13976 12838 PRKG2 HGNC:9416; Q13237...

ADAM12 ADAM28 COL1A1 FN1 IGFALS IGF1, IGF2 HSPA5 Humanin PLG RXRA TF KPNB1 PRKDC EGFR LTBP1 Mecasermin rinfabate, Recombinant IGF-1 with IGFBP-3 used for...