PRPSAP2
Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene.[5]
Function
The enzyme phosphoribosyl pyrophosphate synthetase (PRS) catalyzes the formation of phosphoribosyl pyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141127 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020528 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: phosphoribosyl pyrophosphate synthetase-associated protein 2". Retrieved 2011-08-30.
Further reading
- Katashima R, Iwahana H, Fujimura M, et al. (1998). "Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein". Biochim. Biophys. Acta. 1396 (3): 245–50. doi:10.1016/S0167-4781(97)00217-0. PMID 9545573.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Katashima R, Iwahana H, Fujimura M, et al. (1998). "Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12". Genomics. 54 (1): 180–1. doi:10.1006/geno.1998.5432. PMID 9806849.
- Low SK, Kuchiba A, Zembutsu H, et al. (2010). "Genome-wide association study of pancreatic cancer in Japanese population". PLOS ONE. 5 (7) e11824. Bibcode:2010PLoSO...511824L. doi:10.1371/journal.pone.0011824. PMC 2912284. PMID 20686608.
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