This area was called Ban Pa Mok Noi. In 1585 King Naresuan the Great set his military camp in the area.[1]: 102 Before moving his troops to fight with Burmese troops of Phra Maha Uparacha at Don Chedi, he saluted the big Reclining Buddha in Pa Mok. And he won the war.
During the reign of King Thai Sa, he was the leader of workers who moved the reclining Buddha to save it from flooding.
Pa Mok district was separated from Mueang Ang Thong district and upgraded to a full district in 1902. The first district office was finished in 1904.