Palmoplantar hyperhidrosis is excessive sweating localized to the palms of the hands and soles of the feet. It is a form of focal hyperhidrosis in that the excessive sweating is limited to a specific region of the body. As with other types of focal hyperhidrosis (e.g. axillary and craniofacial) the sweating tends to worsen during warm weather.[1]
Signs and symptoms
Palmoplantar hyperhidrosis is a frequent disorder when excessive amounts of sweat are inappropriately secreted by the eccrine glands in the palms and soles.[2]
Causes
There is little knowledge about the pathogenesis of focal hyperhidrosis. Focal hyperhidrosis may indicate a complicated autonomic nervous system malfunction involving both parasympathetic and sympathetic pathways.[3] Given that 30% to 50% of patients have a family history of hyperhidrosis, there may be a genetic susceptibility.[4]
Diagnosis
Because the excessive sweating is easily noticeable, palmoplantar hyperhidrosis is a clinical diagnosis.[2]
^Bouman, H. D.; Lentzer, E. M. G. (1952). "The treatment of hyperhidrosis of hands and feet with constant current". American Journal of Physical Medicine. 31 (3): 158–169. ISSN0002-9491. PMID14943812.
^Sato, K.; Timm, D. E.; Sato, F.; Templeton, E. A.; Meletiou, D. S.; Toyomoto, T.; Soos, G.; Sato, S. K. (1993-11-01). "Generation and transit pathway of H+ is critical for inhibition of palmar sweating by iontophoresis in water". Journal of Applied Physiology. 75 (5). American Physiological Society: 2258–2264. doi:10.1152/jappl.1993.75.5.2258. ISSN8750-7587.
^Tan, Stephen R.; Solish, Nowell (2002). "Long-Term Efficacy and Quality of Life in the Treatment of Focal Hyperhidrosis with Botulinum Toxin A". Dermatologic Surgery. 28 (6). Ovid Technologies (Wolters Kluwer Health): 495–499. doi:10.1046/j.1524-4725.2002.01159.x. ISSN1076-0512.
^Shelley, W.B.; Talanin, N.Y.; Shelley, E.D. (1998). "Botulinum toxin therapy for palmar hyperhidrosis". Journal of the American Academy of Dermatology. 38 (2). Elsevier BV: 227–229. doi:10.1016/s0190-9622(98)70242-7. ISSN0190-9622. PMID9486678.
Further reading
Iwase, Satoshi; Ikeda, Takehiko; Kitazawa, Hiroki; Hakusui, Shigetaka; Sugenoya, Junichi; Mano, Tadaaki (1997). "Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis". Journal of the Autonomic Nervous System. 64 (2–3). Elsevier BV: 65–73. doi:10.1016/s0165-1838(97)00014-3. ISSN0165-1838.