The Primera División de Fútbol Profesional Apertura 2006 season (officially "Torneo Apertura 2006") started on August 12, 2006 and concluded on December 17.
The team with the lower league position played home in the 1st leg. The 1st legs were played on December 2 and December 3. The 2nd legs were played on December 9 and December 10.
A new rule was introduced this season that clubs can only have three foreign players per club and can only add a new player if there is an injury or player/s is released.