On January 1, 2016, Profondeville had a total population of 12,117. The total area of the municipality is 50.34 km2 (19.44 sq mi) and the population density is 240.70 inhabitants per km².
The original municipality of Profondeville was expanded, during the post-1974 fusion of the Belgian municipalities, with the addition of the ancienne communes of Arbre, Bois-de-Villers, Lesve, Lustin, Rivière and the Lakisse area from the southeast of the newly-adjoining municipality of Floreffe.
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