RASA4

RASA4
Identifiers
AliasesRASA4, CAPRI, GAPL, RAS p21 protein activator 4
External IDsOMIM: 607943; MGI: 1858600; GeneCards: RASA4
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10156

54153

Ensembl

ENSG00000105808

ENSMUSG00000004952

UniProt

O43374

Q6PFQ7

RefSeq (mRNA)

NM_001079877
NM_006989

NM_001039103
NM_133914

RefSeq (protein)

NP_001073346
NP_008920

NP_001034192
NP_598675

Location (UCSC)Chr 7: 102.58 – 102.62 MbChr 5: 136.08 – 136.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[5][6]

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105808 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004952 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776. S2CID 18141962.
  6. ^ a b "Entrez Gene: RASA4 RAS p21 protein activator 4".

Further reading


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