RELT

RELT
Identifiers
AliasesRELT, TNFRSF19L, TRLT, RELT tumor necrosis factor receptor, TNF receptor, RELT TNF receptor, AI3C
External IDsOMIM: 611211; MGI: 2443373; GeneCards: RELT
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

84957

320100

Ensembl

ENSG00000054967

ENSMUSG00000008318

UniProt

Q969Z4

Q8BX43

RefSeq (mRNA)

NM_032871
NM_152222

NM_177073
NM_001358914

RefSeq (protein)

NP_116260
NP_689408

NP_796047
NP_001345843

Location (UCSC)Chr 11: 73.38 – 73.4 MbChr 7: 100.5 – 100.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene.[5][6][7][8][9]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054967 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008318 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB". Blood. 97 (9): 2702–7. doi:10.1182/blood.V97.9.2702. PMID 11313261. S2CID 6347356.
  6. ^ Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P (May 2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human" (PDF). J Biol Chem. 281 (20): 13964–71. doi:10.1074/jbc.M601553200. PMID 16547002.
  7. ^ Polek TC, Talpaz M, Spivak-Kroizman TR (Sep 2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem Biophys Res Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
  8. ^ Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB (Jan 2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem Biophys Res Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
  9. ^ a b "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like".


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