RNF11

RNF11
Identifiers
AliasesRNF11, SID1669, CGI-123, ring finger protein 11
External IDsOMIM: 612598; MGI: 1352759; GeneCards: RNF11
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

26994

29864

Ensembl

ENSG00000123091

ENSMUSG00000028557

UniProt

Q9Y3C5

Q9QYK7

RefSeq (mRNA)

NM_014372

NM_013876

RefSeq (protein)

NP_055187

NP_038904

Location (UCSC)Chr 1: 51.24 – 51.27 MbChr 4: 109.31 – 109.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[5][6][7]

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[7]

See also

Interactions

RNF11 has been shown to interact with RIPK1[8] and STAMBP.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123091 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028557 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (December 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
  6. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. ^ a b "Entrez Gene: RNF11 ring finger protein 11".
  8. ^ Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
  9. ^ Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.

Further reading


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