RNF168

RNF168
Identifiers
AliasesRNF168, hring finger protein 168, RIDL
External IDsOMIM: 612688; MGI: 1917488; GeneCards: RNF168
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.3.2.27↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

165918

70238

Ensembl

ENSG00000163961

ENSMUSG00000014074

UniProt

Q8IYW5

Q80XJ2

RefSeq (mRNA)

NM_152617

NM_027355

RefSeq (protein)

NP_689830

NP_081631

Location (UCSC)Chr 3: 196.47 – 196.5 MbChr 16: 32.1 – 32.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ring finger protein 168 is a protein that in humans is encoded by the RNF168 gene.[5]

This gene encodes an E3 ubiquitin ligase protein that contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in double-strand breaks (DSB) repair. Mutations in this gene result in RIDDLE syndrome.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163961 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014074 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xie T, Qin H, Yuan Z, Zhang Y, Li X, Zheng L (February 2023). "Emerging Roles of RNF168 in Tumor Progression". Molecules. 28 (3). Basel, Switzerland: 1417. doi:10.3390/molecules28031417. PMC 9920519. PMID 36771081.
  6. ^ "RNF168". Reference Sequence Collection; National Center for Biotechnology Information (NCBI). U.S. National Library of Medicine (NLM).

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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