RTL8C

RTL8C
Identifiers
AliasesRTL8C, CXX1, MAR8C, MART8C, Mar8, Mart8, FAM127A, family with sequence similarity 127 member A, SIRH5, retrotransposon Gag like 8C
External IDsOMIM: 300213; MGI: 1920115; GeneCards: RTL8C
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

8933

72865

Ensembl

ENSG00000134590

ENSMUSG00000051851

UniProt

O15255

Q9D6I0

RefSeq (mRNA)

NM_003928
NM_001078171

NM_028375

RefSeq (protein)

NP_001071639

NP_082651

Location (UCSC)Chr X: 135.03 – 135.03 MbChr X: 52.61 – 52.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retrotransposon Gag-like protein 8C is a protein that in humans is encoded by the RTL8C gene (previously FAM127A).[5][6][7][8] An alternative transcription of RTL8C can also produce a longer protein, called CAAX box protein 1.[9][10] RTL8C is part of a family of at least 11 genes that derive from LTR retrotransposons, but no longer function as retrotransposons.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134590 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051851 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frattini A, Faranda S, Zucchi I, Vezzoni P (Jan 1998). "A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916)". Genomics. 46 (1): 167–9. doi:10.1006/geno.1997.5006. PMID 9403077.
  6. ^ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Apr 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
  7. ^ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenet Genome Res. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.
  8. ^ "Entrez Gene: FAM127A family with sequence similarity 127, member A".
  9. ^ "O15255 · CXX1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.
  10. ^ a b "A6ZKI3 · RTL8C_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

Further reading


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