Bull was selected in the 1962 American Football League draft by the Dallas Texans with the team's first pick, but elected to play for the National Football League instead. Bull was taken out of the Baylor University by the Chicago Bears as the seventh pick in the first round in the 1962 NFL draft. During his career, Bull played in 123 games, carried the ball 881 times for 3,222 yards and 9 touchdowns. He was named the 1962 Senior Bowl most valuable player and 1962 UPI NFL-NFC Rookie of the Year. Bull was among the inaugural inductees in the Texas High School Hall of Fame in 1985. He was also inducted into the Chicagoland Sports Hall of Fame in 2001.
He currently runs his specialty advertising business, Ronnie Bull Sales, Inc in the Chicago area.