Vaudetti was born in 1937 in Ancona. She was educated at the University of Turin where she was appointed by Radiotelevisione Italiana around late 1960 and became a television announcer for Secondo Programma in 1961. Vaudetti hosted the Italian game show Games Without Frontiers in the 1970s; she was the Italian commentator for the Eurovision Song Contest seven times and the Italian spokesperson in the contest three times. She was married to television director Antonio Moretti [it].
In April 1999 Vaudetti was appointed Commander of the Italian Republic.