SFRS2IP

SCAF11

Identifiers

SCAF11, CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP, SR-related CTD associated factor 11

External IDs

OMIM: 603668; MGI: 1919443; GeneCards: SCAF11

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q12	Start	45,919,131 bp^[1]
Band	12q12	End	45,992,120 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 F1	Start	96,309,580 bp^[2]
Band	15\|15 F1	End	96,358,724 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

epithelium of colon

tendon of biceps brachii

Achilles tendon

lower lobe of lung

jejunal mucosa

pylorus

tonsil

oral cavity

sural nerve

Top expressed in

tail of embryo

genital tubercle

mandibular prominence

maxillary prominence

epithelium of stomach

ankle

skin of external ear

abdominal wall

tibiofemoral joint

cumulus cell

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding RNA binding
Cellular component	nucleolus nucleus nucleoplasm nuclear body
Biological process	RNA splicing, via transesterification reactions mRNA processing spliceosomal complex assembly RNA splicing
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9169


72193


ENSG00000139218


ENSMUSG00000033228


Q99590


n/a

RefSeq (mRNA)


NM_004719


NM_028148

RefSeq (protein)


NP_004710


n/a

Location (UCSC)

Chr 12: 45.92 – 45.99 Mb

Chr 15: 96.31 – 96.36 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.^[5]^[6]^[7]

Interactions

SFRS2IP has been shown to interact with U2AF2.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139218 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033228 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP (Aug 1997). "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain". Biol Chem. 378 (6): 565–71. doi:10.1515/bchm.1997.378.6.565. PMID 9224939.
^ ^a ^b Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol. 18 (2): 676–84. doi:10.1128/mcb.18.2.676. PMC 108778. PMID 9447963.
^ "Entrez Gene: SFRS2IP splicing factor, arginine/serine-rich 2, interacting protein".

Further reading

Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-14.
van de Craen M, de Jonghe C, van den Brande I, et al. (1999). "Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases" (PDF). FEBS Lett. 445 (1): 149–54. doi:10.1016/S0014-5793(99)00108-8. hdl:10067/238040151162165141. PMID 10069390. S2CID 31218178.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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