Search Results: SIRT4

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Sirtuin
Selasa, 2026-08-11 16:00:48

SIRT7 are predominantly in the nucleus, SIRT2 in the cytoplasm, and SIRT3, SIRT4 and SIRT5 in the mitochondria. Research on sirtuin protein was started in...

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Sirtuin 4
Senin, 2025-09-15 13:12:24

Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family...

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Marcia Haigis
Jumat, 2025-10-03 12:14:42

Guarente. Here she started working on SIRT3, SIRT4, and SIRT5. Amongst her many findings, she showed that SIRT4 repressed glutamate dehydrogenase 1, which...

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UBCS385
Jumat, 2026-01-02 00:03:50

UBCS385 is a drug which acts as a sirtuin-4 (SIRT4) inhibitor. It also inhibits SIRT2 with around the same affinity, but has reasonable selectivity over...

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Glutamate dehydrogenase
Jumat, 2026-04-17 14:47:24

through ADP-ribosylation, a covalent modification carried out by the gene sirt4. This regulation is relaxed in response to caloric restriction and low blood...

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ADP/ATP translocase 2
Kamis, 2026-03-05 02:08:22

ANT2 facilitates uncoupling of the mitochondrial membrane when acylated by SIRT4. Though uncoupling the membrane potential typically leads to apoptosis,...

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RW-93
Jumat, 2026-03-13 05:32:24

over SIRT1, SIRT3 and SIRT5, however its activity has not been reported at SIRT4, SIRT6 or SIRT7. It represents a further development of FM358, which resulted...

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Histone deacetylase
Selasa, 2026-08-11 17:10:25

liver, spleen, kidney – – – III sirtuins in mammals (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7) – – – – – – Sir2 in the yeast S. cerevisiae – – –...

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Methylcrotonyl-CoA carboxylase
Senin, 2025-10-20 11:21:35

that act as reactive acyl species on MCC in a negative feedback loop. SIRT4 activates MCC and upregulates leucine catabolism by removing acyl residues...

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Sirtuin 3
Senin, 2026-08-03 16:40:00

first substrate to bind to SIRT3, prior to NAD+. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in mitochondria and have been implicated in regulating...

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List of human protein-coding genes 7
Rabu, 2026-01-07 00:10:41

Q96EB6 14821 SIRT2 HGNC:10886; Q8IXJ6 14822 SIRT3 HGNC:14931; Q9NTG7 14823 SIRT4 HGNC:14932; Q9Y6E7 14824 SIRT5 HGNC:14933; Q9NXA8 14825 SIRT6 HGNC:14934;...

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Malonyl-CoA decarboxylase
Jumat, 2025-07-18 00:20:09

decarboxylase activity. Similarly, a deacetylation in this specific amino acid by SIRT4 (a mitochondrial protein) represses the enzyme activity, inhibiting fatty...

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