SPRY4

SPRY4
Identifiers
AliasesSPRY4, HH17, sprouty RTK signaling antagonist 4
External IDsOMIM: 607984; MGI: 1345144; GeneCards: SPRY4
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

81848

24066

Ensembl

ENSG00000187678

ENSMUSG00000024427

UniProt

Q9C004

Q9WTP2

RefSeq (mRNA)

NM_001127496
NM_001293289
NM_001293290
NM_030964

NM_011898

RefSeq (protein)

NP_001120968
NP_001280218
NP_001280219
NP_112226

NP_036028

Location (UCSC)Chr 5: 142.31 – 142.33 MbChr 18: 38.72 – 38.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[5][6]

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[6]

Interactions

SPRY4 has been shown to interact with TESK1.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187678 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024427 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
  6. ^ a b "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
  7. ^ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)


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