STARD13

STARD13
Identifiers
AliasesSTARD13, ARHGAP37, DLC2, GT650, LINC00464, StAR related lipid transfer domain containing 13
External IDsOMIM: 609866; MGI: 2385331; GeneCards: STARD13
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

90627

243362

Ensembl

ENSG00000133121

ENSMUSG00000016128

UniProt

Q9Y3M8

Q923Q2

RefSeq (mRNA)

NM_001163493
NM_146258
NM_001359985

RefSeq (protein)

NP_001156965
NP_666370
NP_001346914

Location (UCSC)Chr 13: 33.1 – 33.35 MbChr 5: 150.96 – 151.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.[5][6]

Function and structure

STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.[7] It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.[7]

The protein consists of an N-terminal sterile alpha motif (SAM) domain,[8] a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).

Tissue distribution and pathology

The protein was identified in part through its differential expression in cancers. A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression. A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133121 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016128 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Couch FJ, Rommens JM, Neuhausen SL, Bélanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J (August 1996). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99. doi:10.1006/geno.1996.0428. PMID 8812419.
  6. ^ "Entrez Gene: STARD13 START domain containing 13".
  7. ^ a b Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO (March 2003). "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry. 278 (12): 10824–30. doi:10.1074/jbc.M208310200. PMID 12531887.
  8. ^ Li, Hongyan; Fung, King-Leung; Jin, Dong-Yan; Chung, Stephen S. M.; Ching, Yick-Pang; Ng, Irene Oi-lin; Sze, Kong-Hung; Ko, Ben C. B.; Sun, Hongzhe (2007-06-01). "Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2". Proteins. 67 (4): 1154–1166. doi:10.1002/prot.21361. ISSN 1097-0134. PMID 17380510. S2CID 20407564.
  9. ^ Xiaorong L, Wei W, Liyuan Q, Kaiyan Y (2008). "Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma". BMC Cancer. 8 205. doi:10.1186/1471-2407-8-205. PMC 2496915. PMID 18651974.

Further reading

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