STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.[5]
Function
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene may be involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Bi YW, Wang CM, Yan ZT, Li NF, Guo YY, Wang HM, Yao XG, Liang DP (February 2011). "[Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 64–8. doi:10.3760/cma.j.issn.1003-9406.2011.01.015. PMID21287513.
Guo YY, Li NF, Wang CM, Yan ZT, Zhang JH, Wang HM, Zhou L, Luo WL (February 2011). "[Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 78–82. doi:10.3760/cma.j.issn.1003-9406.2011.01.018. PMID21287516.
Nanfang L, Yanying G, Hongmei W, Zhitao Y, Juhong Z, Ling Z, Wenli L (August 2010). "Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population". Archives of Medical Research. 41 (6): 449–56. doi:10.1016/j.arcmed.2010.08.006. PMID21044749.
Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T (February 2012). "Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis". Modern Rheumatology. 22 (1): 128–36. doi:10.1007/s10165-011-0475-y. PMID21633911. S2CID21108512.
Guo YY, Li NF, Zhou L, Yao XG, Wang HM, Zhang JH, Luo WL (July 2011). "A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population". Chinese Medical Journal. 124 (14): 2096–100. PMID21933608.
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
