SYCP3

SYCP3
Identifiers
AliasesSYCP3, COR1, SCP3, SPGF4, RPRGL4, synaptonemal complex protein 3
External IDsOMIM: 604759; MGI: 109542; GeneCards: SYCP3
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

50511

20962

Ensembl

ENSG00000139351

ENSMUSG00000020059

UniProt

Q8IZU3

P70281

RefSeq (mRNA)

NM_001177948
NM_001177949
NM_153694

NM_011517

RefSeq (protein)

NP_001171419
NP_001171420
NP_710161

NP_035647

Location (UCSC)Chr 12: 101.73 – 101.74 MbChr 10: 88.3 – 88.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene.[5][6][7] It is a component of the synaptonemal complex formed between homologous chromosomes during the prophase of meiosis.[8]

Gene family

XLR/SYCP3/FAM9 domain
Identifiers
SymbolCor1
PfamPF04803
InterProIPR006888
CATH4cpc
Available protein structures:
PDB  IPR006888 PF04803 (ECOD; PDBsum)  
AlphaFold

SYCP3 is also known as COR1. It contains a conserved coiled-coil domain that is also found in the FAM9 (FAM9A, FAM9B) family of proteins, found on the human X chromosome.[5]

Several SYCP3-like proteins are found on mice sex chromosomes. They are assigned names starting with Slx or Sly depending on the chromosome they are linked to. Slx/Slxl1 and Sly are neofunctionalized ones that have opposite effects on gene expression and epigenetic modifications, and each gene reduces the viability and mobility (via spindlin binding) of sperms containing the other sex chromosome, tilting the sex ratio to their own favor.[9] Over time they are duplicated to balance out each other's effects.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139351 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020059 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Martinez-Garay I, Jablonka S, Sutajova M, Steuernagel P, Gal A, Kutsche K (September 2002). "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region". Genomics. 80 (3): 259–67. doi:10.1006/geno.2002.6834. PMID 12213195.
  6. ^ Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, et al. (June 2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Research. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
  7. ^ "Entrez Gene: SYCP3 synaptonemal complex protein 3".
  8. ^ Syrjänen JL, Pellegrini L, Davies OR (June 2014). "A molecular model for the role of SYCP3 in meiotic chromosome organisation". eLife. 3. doi:10.7554/eLife.02963. PMC 4102245. PMID 24950965.
  9. ^ Cocquet J, Ellis PJ, Mahadevaiah SK, Affara NA, Vaiman D, Burgoyne PS (September 2012). "A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse". PLOS Genetics. 8 (9) e1002900. doi:10.1371/journal.pgen.1002900. PMC 3441658. PMID 23028340.
  10. ^ Kruger AN, Brogley MA, Huizinga JL, Kidd JM, de Rooij DG, Hu YC, Mueller JL (October 2019). "A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice". Current Biology. 29 (21): 3699–3706.e5. doi:10.1016/j.cub.2019.08.057. PMC 7012382. PMID 31630956.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q8IZU3 (Human Synaptonemal complex protein 3) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: P70281 (Mouse Synaptonemal complex protein 3) at the PDBe-KB.
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