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initiated when the cytosolic Ras GTPase Sar1 is activated by its guanine nucleotide exchange factor Sec12. Activated Sar1-GTP inserts itself into the ER membrane...

GDP for GTP on Sar1. This activates the Sar1 protein, causing its amphipathic alpha helix to bind to the ER membrane. Membrane bound Sar1 attracts the Sec23-Sec24...

with a protein called Sec12. This protein recruits a small GTPase called Sar1. Sar1 can be thought of as a switch which is active when bound to GTP and inactive...

N(cookie),sai1,kei,Ni----------------> | | <--------------------------HDR(A,B),SAr1,ker,Nr| If HostB (the responder) is experiencing large amounts of half-open...

and endocytic pathways controlling the dendritic development include DAR3 /SAR1, DAR2/Sec23, DAR6/Rab1, etc.... All these molecules interplay with each other...

2 Illustration, same variant, fully orange Search and rescue boat Dagmar SAR1 2007 Used from the Knud Rasmussen class, modified with ice-reinforcements...

budding from the ER. COPII coats consist of the small GTP-binding protein Sar1 and two additional complexes: Sec23/Sec24 and Sec13/Sec31. These coat proteins...

electronic rhythm machine with pre-programmed patterns, Select-A-Rhythm (SAR1), was released. As a result of its robustness and enough compact size, these...

the fact that its RasGAP-related domain (GRD) has sequence homology to the Sar1 GTPase. It was hypothesized that IQGAP1 would act as a GTPase activating...

Figure 5. PDE5 SAR1...

and activation of the small GTPase SAR1, which exists in a soluble cytoplasmic form when in its GDP-bound state. SAR1 is promoted by SEC12, a membrane-bound...

PMID 3792776. Jones B, Jones EL, Bonney SA, et al. (May 2003). "Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders"...

The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues)...

2007). "Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31". Developmental Cell. 13 (5):...

COPII coat complex (Sec23 and Sec24), ER exit site factors (Sec12, Sec16, Sar1, and Tango1), membrane tethering complexes (TRAPP and COG complex subunits)...

COPII coat complex (Sec23 and Sec24), ER exit site factors (Sec12, Sec16, Sar1, and Tango1), membrane tethering complexes (TRAPP and COG complex subunits)...

recruit the BBSome to the ciliary membranes. It is comparable to Arf1 and Sar1 in COPI/COPII and clathrin coats. The BBSome complex begins with a conformation...