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encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs...

Nichols RJ, Koltun ES, Yang YC, Wildes DP, et al. (2020). "Abstract 1943: SHP2 inhibition as the backbone of targeted therapy combinations for the treatment...

acts as a selective inhibitor of the protein tyrosine phosphatase enzyme SHP2, which regulates cell growth and differentiation through the MAPK signaling...

non-RTK receptors serving as the gateway into the cell for activation of SHP2, Phosphatidylinositol 3-kinase (PI3K), Grb2, ERK, and AKT and acting as one...

Garcia-Fortanet J, Acker MG, et al. (July 2016). "Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases". Nature...

Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312". Cancer Research Communications. 5 (5): 792–803. doi:10...

and writers". shp2.amsab.be. Retrieved 15 October 2024. Evans, Harold (2017). "Do I make myself clear? Why writing well matters". shp2.amsab.be. Retrieved...

membrane-associated tyrosine kinase (TK). CagA then allosterically activates Shp2, a protein tyrosine phosphatase and protooncogene. These proteins are directly...

NCT01676259). In glioblastoma mouse models SHP2 levels were heightened in cancerous brain cells. Inhibiting SHP2 in turn inhibited Ras dephosphorylation...

JAK2 activity, and promote JAK2/STAT5 signalling. It is still unknown how SHP2 can both inhibit and promote JAK-STAT signalling in the JAK2/STAT5 pathway;...

Heemskerk, Johan W.M.; Kuijpers, Marijke J.E.; García, Ángel (2023). "Role of SHP2 (PTPN11) in glycoprotein VI-dependent thrombus formation: Improved platelet...

organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4):...

to the plasma membrane. For example, β1c integrin recruits Gab1/Shp2 and presents Shp2 to IGF1R, resulting in dephosphorylation of the receptor. In a reverse...

in human breast cancer cell line MDA-MB-231 and human fibroblasts through SHP2 activation". Medicinal Chemistry. 4 (3): 219–228. doi:10.2174/157340608784325179...

structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al...

signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this...

ligation, SIRPα is phosphorylated and recruits phosphatases like SHP1 and SHP2. The extracellular region contains three Immunoglobulin superfamily domains...

Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation...

proteins bearing SH2 homology domain, such as PI3K, Grb-2/Sos complex and SHP2. PI3K, involved in interaction with IRS-1, produces PIP3, which, in turn...

and other cellular proteins, such as GRB2, IRS1, Shc, Src, FRS2, PTPN11/Shp2, PLCγ, PI3K, and NF1. Other reported downstream ALK targets include FOXO3a...

(ITIM) on the other hand recruit the cytoplasmic tyrosine phosphates SHP1, SHP2 and the phosphatidylinositol phosphatase SHIP-1. The phosphatases can attenuate...

T468M[dead link]) the mutations cause a loss of catalytic activity of the SHP2 protein (the gene product of the PTPN11 gene), which is a previously unrecognized...

tool in intellectually disabled males. ACSL1 expression is regulated by SHP2 activity. Additionally, ACSL1 interacts with ACSL3, APP, DSE, ELAVL1, HECW2...

to the membrane by the Grb2 SH2 domain binding to activated PDGFR-bound SHP2 (also known as PTPN11, a cytosolic PTP), thereby allowing interaction with...

the position in the biochemical pathway occupied by the affected genes. Shp2, the protein product of the PTPN11 gene, appears to regulate the MAP kinase...

inhibitor, for the treatment of NSCLC (NCT05789082), and with experimental SHP2 inhibitors to address potential resistance mechanisms. Divarasib is currently...

Weissenbach M, Sobota RM, Hortner M, Friederichs K, et al. (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling...

involved in the recruitment of GRB2, phospholipase C γ (PLC-γ), p85, and SHP2. GAB1 is a key coordinator of the cellular responses to MET and binds the...

Liu Y, Zhang Y, et al. (November 2025). "Discovery of SA-8 as a potent SHP2-AUTAC degrader in cancer therapy". European Journal of Medicinal Chemistry...

polyinositol phosphatase-1 SHP1 SH2-domain-containing phosphatase-1; PTP SHP2 SH2-domain-containing phosphatase-2; PTP PKC-δ Protein kinase C-d Pkare PKA-related...

BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains". Proc. Natl. Acad. Sci. U.S.A. 110 (37): 14924–9. Bibcode:2013PNAS...

Weissenbach M, Sobota RM, Hortner M, Friederichs K, et al. (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling...

(2001). "A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal...

Weissenbach M, Sobota RM, Hortner M, Friederichs K, et al. (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling...

Class C: AGAMOUS (AG) Class D: SEEDSTICK (STK), SHATTERPROOF1 (SHP1), and SHP2 Class E: SEPALLATA1-4 (SEP1-SEP4). Class E proteins are structural components...

Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". The Journal of Biological Chemistry. 275 (23): 17263–8. doi:10...

Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C (August 2010). "Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase...

S2CID 2668221. Ukropec JA, Hollinger MK, Salva SM, Woolkalis MJ (2000). "SHP2 association with VE-cadherin complexes in human endothelial cells is regulated...

2001). "Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine...

2016). "A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor...

"Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2". The Journal of Biological Chemistry. 272 (17): 10998–1001. doi:10.1074/jbc...

with Alport syndrome and elliptocytosis. ACSL4 expression is regulated by SHP2 activity. Additionally, ACSL4 interacts with ACSL3, APP, DSE, ELAVL1, HECW2...

(July 1999). "Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical...

Eklund EA (2006). "Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the...

protein. DDR2 (gene) has been shown to interact with SHC1 and phosphorylate Shp2. DDR2 also interacts with Integrin α1β1 and α2β1 by promoting their adhesion...

inhibitory. The inhibitory signal is mediated by binding of phosphatases SHP1, SHP2, SHIP-1 or the kinase CsK on the third ITSM. Activating signaling is associated...

p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2". The Journal of Biological Chemistry. 272 (25): 15636–15641. doi:10.1074/jbc...

as a scaffold protein to hold GAB1 and GRB2 which then proteins bind to SHP2 and SOS. These several proteins act together to activates the Ras pathway...

of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated...

PMID 10940929. Hadari YR, Kouhara H, Lax I, Schlessinger J (July 1998). "Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced...

PMID 12815057. Hanafusa H, Torii S, Yasunaga T, Matsumoto K, Nishida E (May 2004). "Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor...

PMID 11360177. Hadari YR, Kouhara H, Lax I, Schlessinger J (July 1998). "Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced...

N, Sikorska J, Krausze J, et al. (January 2020). "Molecular mechanism of SHP2 activation by PD-1 stimulation". Science Advances. 6 (5) eaay4458. doi:10...

receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2". J Biol Chem. 281 (49): 37758–37772. doi:10.1074/jbc.M605756200. PMID 17018529...

reduced ARSB is associated with carcinogenesis is through increased binding of SHP2 to more sulfated chondroitin 4-sulfate, which leads to increased phosphorylation...

Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". J. Biol. Chem. 275 (23): 17263–8. doi:10.1074/jbc.M000689200....

Tai YT, Rosen S, Avraham S, Kharbanda S, Anderson KC (September 2000). "SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced...

Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". The Journal of Biological Chemistry. 275 (23): 17263–8. doi:10...

containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells". Biochimica et Biophysica Acta (BBA) - Molecular Basis of...

p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2". Journal of Biological Chemistry. 272 (25): 15636–15641. doi:10.1074/jbc...

tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes". Biochem. J. 388 (Pt 1): 17–28. doi:10.1042/BJ20041236...

of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated...

An additional mechanism proposes that binding of the tyrosine phosphatase Shp2 to the netrin-1/UNC-5 complex may also trigger chemorepulsion through RhoA...