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Simplexvirus
Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Humans and mammals serve as natural hosts. Diseases associated with this genus include skin vesicles or mucosal ulcers, rarely encephalitis, and meningitis.[1][2] SpeciesThe following 17 species are assigned to the genus in ICTV 2022:[2]
StructureViruses in Simplexvirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and unsegmented, around 152kb in length.[1]
LifecycleViral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral gB, gC, gD, and gH proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism, is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress, budding, and microtubular outwards viral transport. Human and mammals serve as the natural hosts. Transmission routes are sexual, contact, and saliva.[1]
References
External links Wikimedia Commons has media related to Simplexvirus.  Wikispecies has information related to Simplexvirus.
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