Spectrin repeat
| Spectrin repeat | |||||||
|---|---|---|---|---|---|---|---|
 Structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.[1] | |||||||
| Identifiers | |||||||
| Symbol | Spectrin | ||||||
| Pfam | PF00435 | ||||||
| Pfam clan | CL0743 | ||||||
| ECOD | 604.1.1 | ||||||
| InterPro | IPR002017 | ||||||
| PROSITE | PDOC50083 | ||||||
| SCOP2 | 1aj3 / SCOPe / SUPFAM | ||||||
| CDD | cd00176 | ||||||
| |||||||
Spectrin repeats[2] are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin, dystrophin and more recently the plakin family. The spectrin repeat forms a three-helix bundle. These conform to the rules of the heptad repeat. Spectrin repeats give rise to linear proteins. This however may be due to sample bias in which linear and rigid structures are more amenable to crystallization. There are hints however, that some proteins harbouring spectrin repeats may also be flexible. This is most likely due to specifically evolved functional purposes.
Human proteins containing this domain
ACTN1; ACTN2; ACTN3; ACTN4; AKAP6; SYNE3; CATX-15; DMD; DRP2; DST; KALRN; MACF1; MCF2L; SPTA1; SPTAN1; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5; SYNE1; SYNE2; TRIO; UTRN;
References
- ^ Pascual J, Pfuhl M, Walther D, Saraste M, Nilges M (October 1997). "Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil". J. Mol. Biol. 273 (3): 740–51. doi:10.1006/jmbi.1997.1344. PMID 9356261.
- ^ Harrison SC, Yan Y, Winograd E, Viel A, Cronin T, Branton D (1993). "Crystal structure of the repetitive segments of spectrin". Science. 262 (5142): 2027–2030. doi:10.1126/science.8266097. PMID 8266097.
- Jefferson, JJ; Ciatto, C; Shapiro, L; Liem, RK (2007). "Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily". Journal of Molecular Biology. 366 (1): 244–57. doi:10.1016/j.jmb.2006.11.036. PMC 1850962. PMID 17161423.
- Grum, VL; Li, D; MacDonald, RI; Mondragón, A (1999). "Structures of two repeats of spectrin suggest models of flexibility". Cell. 98 (4): 523–35. doi:10.1016/S0092-8674(00)81980-7. PMID 10481916. S2CID 1710820.
Further reading
- Djinovic-Carugo K, Gautel M, Ylänne J, Young P (February 2002). "The spectrin repeat: a structural platform for cytoskeletal protein assemblies". FEBS Lett. 513 (1): 119–23. doi:10.1016/S0014-5793(01)03304-X. PMID 11911890. S2CID 10581541.
- Pascual J, Castresana J, Saraste M (September 1997). "Evolution of the spectrin repeat". BioEssays. 19 (9): 811–7. doi:10.1002/bies.950190911. PMID 9297972. S2CID 42145758.
- Al-Jassar, C; Knowles, T; Jeeves, M; Kami, K; Behr, E; Bikker, H; Overduin, M; Chidgey, M (Jul 2, 2011). "The Nonlinear Structure of the Desmoplakin Plakin Domain and the Effects of Cardiomyopathy-Linked Mutations". Journal of Molecular Biology. 411 (5): 1049–61. doi:10.1016/j.jmb.2011.06.047. PMID 21756917.
 | This membrane protein–related article is a stub. You can help Wikipedia by adding missing information. |
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.