SroB RNA

sroB RNA
Predicted secondary structure and sequence conservation of sroB
Identifiers
SymbolsroB
RfamRF00368
Other data
RNA typeGene; sRNA
DomainBacteria
SOSO:0000655
PDB structuresPDBe

The sroB RNA (also known as MicM, rybC, or ChiX) is a non-coding RNA gene of 90 nucleotides in length. sroB is found in several Enterobacterial species, but its function is unknown.[1][2] SroB is found in the intergenic region on the opposite strand to the ybaK and ybaP genes.[1] SroB is expressed in stationary phase.[1] Experiments have shown that SroB is a Hfq binding sRNA.[2][3]

Further evidence has shown that SroB negatively regulates the outer membrane protein YbfM by sequestering the ribosome binding site of ybfM mRNA by an antisense interaction.[4] SroB also regulates the DpiA/DpiB two-component system.[5] Furthermore, SroB itself appears to be the target of a non-coding transcript from the chbBC intergenic region.[6][7][8]

References

  1. ^ a b c Vogel J, Bartels V, Tang TH, et al. (2003). "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Res. 31 (22): 6435–6443. doi:10.1093/nar/gkg867. PMC 275561. PMID 14602901.
  2. ^ a b Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S (November 2003). "Global analysis of small RNA and mRNA targets of Hfq". Mol. Microbiol. 50 (4): 1111–1124. doi:10.1046/j.1365-2958.2003.03734.x. PMID 14622403. S2CID 40056275.
  3. ^ Sittka A, Lucchini S, Papenfort K, et al. (2008). Burkholder WF (ed.). "Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq". PLOS Genet. 4 (8) e1000163. doi:10.1371/journal.pgen.1000163. PMC 2515195. PMID 18725932.
  4. ^ Rasmussen AA, Johansen J, Nielsen JS, Overgaard M, Kallipolitis B, Valentin-Hansen P (April 2009). "A conserved small RNA promotes silencing of the outer membrane protein YbfM". Mol. Microbiol. 72 (3): 566–577. doi:10.1111/j.1365-2958.2009.06688.x. PMID 19400782. S2CID 24575908.
  5. ^ Mandin, P.; Gottesman, S. (2009). "A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system". Molecular Microbiology. 72 (3): 551–565. doi:10.1111/j.1365-2958.2009.06665.x. PMC 2714224. PMID 19426207.
  6. ^ Overgaard M, Johansen J, Møller-Jensen J, Valentin-Hansen P (2009). "Switching off small RNA regulation with trap-mRNA". Mol Microbiol. 73 (5): 790–800. doi:10.1111/j.1365-2958.2009.06807.x. PMID 19682266.
  7. ^ Vogel J (July 2009). "An RNA trap helps bacteria get the most out of chitosugars". Mol. Microbiol. 73 (5): 737–741. doi:10.1111/j.1365-2958.2009.06806.x. PMID 19659640. S2CID 26358452.{{cite journal}}: CS1 maint: deprecated archival service (link)
  8. ^ Figueroa-Bossi N, Valentini M, Malleret L, Fiorini F, Bossi L (2009). "Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target". Genes Dev. 23 (17): 2004–2015. doi:10.1101/gad.541609. PMC 2751969. PMID 19638370.

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