SroC RNA

sroC RNA
Predicted secondary structure and sequence conservation of sroC
Identifiers
SymbolsroC
RfamRF00369
Other data
RNA typeGene; sRNA
DomainBacteria
SOSO:0000655
PDB structuresPDBe

The bacterial SroC RNA is a non-coding RNA gene of around 160 nucleotides in length. SroC is found in several enterobacterial species.[1] This RNA interacts with the Hfq protein.

SroC acts as a ‘sponge,’ and base pairs with and regulates activity of the sRNA GcvB. This interaction triggers the degradation of GcvB by RNase E, alleviating the GcvB-mediated mRNA repression of other amino acid-related transport and metabolic genes.[2][3]

References

  1. ^ Vogel J, Bartels V, Tang TH, Churakov G, Slagter-Jäger JG, Hüttenhofer A, Wagner EG (November 2003). "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Research. 31 (22): 6435–43. doi:10.1093/nar/gkg867. PMC 275561. PMID 14602901.
  2. ^ Miyakoshi M, Chao Y, Vogel J (June 2015). "Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA". The EMBO Journal. 34 (11): 1478–92. doi:10.15252/embj.201490546. PMC 4474525. PMID 25630703.
  3. ^ Azam MS, Vanderpool CK (June 2015). "Talk among yourselves: RNA sponges mediate cross talk between functionally related messenger RNAs". The EMBO Journal. 34 (11): 1436–8. doi:10.15252/embj.201591492. PMC 4474520. PMID 25916829.
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