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TAF4B
Identifiers
Aliases	TAF4B, SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDs	OMIM: 601689; MGI: 2152345; GeneCards: TAF4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H3O, 2P6V
Gene location (Human)
Chr.	Chromosome 18 (human)
End	26,391,685 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	15,033,416 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; gonad; ; testicle; ; Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; cartilage tissue; ; Achilles tendon; ; tibialis anterior muscle;
	Top expressed in
	Epithelium of choroid plexus; ; lumbar spinal ganglion; ; hand; ; Gonadal ridge; ; otolith organ; ; utricle; ; Paneth cell; ; cumulus cell; ; oocyte; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; NF-kappaB binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding; RNA polymerase II general transcription initiation factor activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; fibrillar center; transcription factor TFIID complex;
Biological process	DNA-templated transcription, initiation; cell differentiation; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription by RNA polymerase II; spermatogenesis; transcription, DNA-templated; oogenesis; regulation of signal transduction by p53 class mediator; positive regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6875
	72504
	ENSG00000141384
	ENSMUSG00000054321
	Q92750
	G5E8Z2
	NM_001293725; NM_005640
	NM_001100449; NM_001369357; NM_001369358
	NP_001280654; NP_005631
	NP_001093919; NP_001356286; NP_001356287
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.^[5]^[6]^[7]

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM]^[7]

Interactions

TAF4B has been shown to interact with RELA.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.
^ Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.
^ ^a ^b "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
^ Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity". Mol. Cell. 29 (1): 81–91. doi:10.1016/j.molcel.2007.11.003. PMC 2486835. PMID 18206971.
Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem. 96 (4): 751–9. doi:10.1002/jcb.20577. PMID 16088961. S2CID 23658728.
Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes". Mol. Cell. Biol. 25 (1): 206–19. doi:10.1128/MCB.25.1.206-219.2005. PMC 538770. PMID 15601843.
Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105". J. Biol. Chem. 276 (48): 44963–9. doi:10.1074/jbc.M106112200. PMID 11567023.
Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription". J. Biol. Chem. 275 (22): 16459–65. doi:10.1074/jbc.275.22.16459. PMID 10828057.
Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8858156-5] Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.

[pmid10849440-6] Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.

[entrez-7] "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".

[pmid9724652-8] Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

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TAF4B

Function

Interactions

References

Further reading

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