TELO2

TELO2
Identifiers
AliasesTELO2, CLK2, TEL2, telomere maintenance 2, YHFS
External IDsOMIM: 611140; MGI: 1918968; GeneCards: TELO2
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9894

71718

Ensembl

ENSG00000100726

ENSMUSG00000024170

UniProt

Q9Y4R8

Q9DC40

RefSeq (mRNA)

NM_016111
NM_001351846

NM_001163661
NM_027880

RefSeq (protein)

NP_057195
NP_001338775

NP_001157133
NP_082156

Location (UCSC)Chr 16: 1.49 – 1.51 MbChr 17: 25.32 – 25.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.[5][6][7][8]

Function

In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR and is a highly conserved regulator of PIKK stability.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100726 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024170 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. ^ Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
  8. ^ "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
  9. ^ Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9Y4R8 (Human Telomere length regulation protein TEL2 homolog) at the PDBe-KB.
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