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TEX11
Identifiers
Aliases	TEX11, TGC1, TSGA3, SPGFX2, testis expressed 11, ZIP4, MZIP4, Spo22, ZIP4H
External IDs	OMIM: 300311; MGI: 1933237; GeneCards: TEX11
Gene location (Human)
Chr.	X chromosome (human)
End	70,908,711 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,103,273 bp
RNA expression pattern
	Top expressed in
	sperm; ; gonad; ; body of pancreas; ; testicle; ; right testis; ; left testis; ; Epithelium of choroid plexus; ; mucosa of transverse colon; ; pancreatic epithelial cell; ; mucosa of sigmoid colon;
	Top expressed in
	spermatid; ; zygote; ; secondary oocyte; ; spermatocyte; ; embryo; ; embryo; ; primary oocyte; ; seminiferous tubule; ; Gonadal ridge; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	central element; condensed nuclear chromosome; chromosome; synaptonemal complex;
Biological process	fertilization; chiasma assembly; male meiosis chromosome segregation; synaptonemal complex assembly; resolution of meiotic recombination intermediates; negative regulation of apoptotic process; meiosis; male meiotic nuclear division; male gonad development; meiotic gene conversion; reciprocal meiotic recombination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56159
	83558
	ENSG00000120498
	ENSMUSG00000009670
	Q8IYF3
	Q14AT2
	NM_001003811; NM_031276
	NM_001167997; NM_031384
	NP_001003811; NP_112566
	NP_001161469; NP_113561
	Wikidata
View/Edit Human	View/Edit Mouse

Testis expressed 11 is a protein that in humans is encoded by the TEX11 gene.^[5]

Function

This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120498 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009670 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Testis expressed 11". Retrieved 2018-03-03.

Wang PJ, McCarrey JR, Yang F, Page DC (April 2001). "An abundance of X-linked genes expressed in spermatogonia". Nat. Genet. 27 (4): 422–6. doi:10.1038/86927. PMID 11279525. S2CID 14200121.
Aston KI, Krausz C, Laface I, Ruiz-Castané E, Carrell DT (June 2010). "Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent" (PDF). Hum. Reprod. 25 (6): 1383–97. doi:10.1093/humrep/deq081. PMID 20378615.
Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe T, Olszewska M, Westernströer B, Sanfilippo J, Kurpisz M, Rajkovic A, Yatsenko SA, Kliesch S, Schlatt S, Tüttelmann F (May 2015). "X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men". N. Engl. J. Med. 372 (22): 2097–107. doi:10.1056/NEJMoa1406192. PMC 4470617. PMID 25970010.
Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ (September 2015). "TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse". EMBO Mol Med. 7 (9): 1198–210. doi:10.15252/emmm.201404967. PMC 4568952. PMID 26136358.
Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ (September 2015). "TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse". EMBO Mol Med. 7 (9): 1198–210. doi:10.15252/emmm.201404967. PMC 4568952. PMID 26136358.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120498 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009670 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Testis expressed 11". Retrieved 2018-03-03.

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TEX11

Function

References

Further reading

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